Exosomes in the Oncobiology, Diagnosis, and Therapy of Hepatic Carcinoma: A New Player of an Old Game

BioMed Research International
Fang SunQin Pan

Abstract

Exosomes are emerging as essential vehicles mediated cross-talk between different types of cells in tumor microenvironment. The extensive exploration of exosomes in hepatocellular carcinoma (HCC) enhances our comprehension of cancer biology referring to tumor growth, metastasis, immune evasion, and chemoresistance. Besides, the versatile roles of exosomes provide reasonable explanations for the propensity for liver metastasis of gastric cancer, pancreatic ductal adenocarcinoma, breast cancer, and colorectal cancer. The selective-enriched components, especially some specific proteins and noncoding RNAs in exosomes, have great potential as noninvasive biomarkers of HCC with high sensitivity and specificity. The characteristics of exosomes further inspire frontier research to interrupt intercellular malignant signals by controlling the biogenesis, release, or contents of exosomes.

References

Apr 16, 2009·Journal of Proteome Research·Javier Conde-VancellsJuan M Falcon-Perez
Sep 29, 2009·Biochimica Et Biophysica Acta·Claudio Marcelo FaderMaría Isabel Colombo
Dec 8, 2009·Nature Cell Biology·Matias OstrowskiClotilde Thery
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sayaka InokuchiEkihiro Seki
Apr 21, 2010·The Journal of Cell Biology·Chieh HsuMikael Simons
Jul 1, 2010·Nature Reviews. Molecular Cell Biology·James H Hurley, Phyllis I Hanson
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jul 2, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Takayuki KogureTushar Patel
Aug 31, 2011·F1000 Biology Reports·Clotilde Théry
Oct 4, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ritu JaiswalMary Bebawy
Oct 13, 2011·Nucleic Acids Research·Suresh MathivananRichard J Simpson
Jul 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Vedashree RamakrishnaiahLuc J W van der Laan
May 16, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rui-Min ChangLian-Yue Yang
May 31, 2014·Molecular Cancer Research : MCR·Kenji TakahashiTushar Patel
Aug 2, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Luisa PascucciAugusto Pessina
Dec 17, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jin-xing WeiJun Min
Apr 8, 2015·Biochemical and Biophysical Research Communications·Jae-Jun BanManho Kim
Sep 19, 2015·Experimental & Molecular Medicine·Won SohnYong-Han Paik
Nov 3, 2015·Nature·Ayuko HoshinoDavid Lyden
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Mar 19, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Quan RaoHaiFang Yin
Apr 2, 2016·The Journal of Clinical Investigation·Rong XuRichard J Simpson
Apr 2, 2016·The Journal of Clinical Investigation·Jonathan M PittLaurence Zitvogel
Apr 8, 2016·Cellular and Molecular Neurobiology·Erik R Abels, Xandra O Breakefield

❮ Previous
Next ❯

Citations

May 17, 2019·Journal of Cellular Physiology·Weijia Han, Zhongping Duan
Jul 3, 2021·International Journal of Molecular Sciences·Mengtao XingJian-Ying Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
transmission
dynamic light scattering
flow cytometry
GTPases
xenograft

Software Mentioned

EVpedia
Exocarta
Vesiclepedia

Related Concepts

Related Feeds

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

© 2022 Meta ULC. All rights reserved