Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice

Oncotarget
Yungang WangShengjun Wang

Abstract

Myeloid-derived suppressor cells (MDSC) have been described in inflammatory bowel disease (IBD), but their role in the disease remains controversial. We sought to define the effect of granulocytic MDSC-derived exosomes (G-MDSC exo) in dextran sulphate sodium (DSS)-induced murine colitis. G-MDSC exo-treated mice showed greater resistance to colitis, as reflected by lower disease activity index, decreased inflammatory cell infiltration damage. There was a decrease in the proportion of Th1 cells and an increase in the proportion of regulatory T cells (Tregs) in mesenteric lymph nodes (MLNs) from G-MDSC exo-treated colitis mice. Moreover, lower serum levels of interferon (IFN)-γ and tumor necrosis factor (TNF)-α were detected in G-MDSC exo-treated colitis mice. Interestingly, inhibition of arginase (Arg)-1 activity in G-MDSC exo partially abrogated the spontaneous improvement of colitis. In addition, G-MDSC exo could suppress CD4+ T cell proliferation and IFN-γ secretion in vitro and inhibit the delayed-type hypersensitivity (DTH) response, and these abilities were associated with Arg-1 activity. Moreover, G-MDSC exo promoted the expansion of Tregs in vitro. Taken together, these results suggest that G-MDSC exo attenuate DSS-induce...Continue Reading

References

Apr 16, 2002·The Journal of Biological Chemistry·Paulo C RodriguezAugusto C Ochoa
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sergei KusmartsevDmitry I Gabrilovich
Jul 3, 2007·Nature Medicine·Srinivas NagarajDmitry I Gabrilovich
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Mar 5, 2011·Biochemical Pharmacology·Michel RecordMarc Poirot
Jan 3, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marianna IoannouPanayotis Verginis
Jan 6, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dmitry V OstaninMatthew B Grisham
Mar 23, 2012·Nature Reviews. Immunology·Dmitry I GabrilovichVincenzo Bronte
Jun 23, 2012·Pharmacological Reviews·Edwin van der PolRienk Nieuwland
Jun 28, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wataru FujiiYutaka Kawahito
Jul 3, 2013·Inflammatory Bowel Diseases·Dmitry V Ostanin, Dhruva Bhattacharya
Jul 31, 2013·Pharmaceuticals·Michelle E Marcus, Joshua N Leonard
Sep 7, 2013·Journal of Extracellular Vesicles·Stephen J Gould, Graça Raposo
Sep 17, 2013·International Immunopharmacology·Elaine F C ReisAna Paula Ferreira
Dec 4, 2013·Journal of Proteome Research·Meghan BurkeCatherine Fenselau
Jan 11, 2014·Seminars in Immunology·Lida A Beninson, Monika Fleshner
Apr 4, 2014·Journal of Leukocyte Biology·Elvira KurmaevaDmitry V Ostanin
Jan 17, 2015·Frontiers in Medicine·Mehmet Coskun
Jan 27, 2015·World Journal of Immunology·Kristen R Crook, Peng Liu
Mar 3, 2015·Therapeutic Advances in Gastroenterology·Aurelien Amiot, Laurent Peyrin-Biroulet
May 2, 2015·Intestinal research·Yeon-Jeong KimHyun-Jeong Ko
Jun 2, 2015·Expert Review of Clinical Immunology·Hui YangGuangwei Liu
Jun 21, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jie TianShengjun Wang

❮ Previous
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Citations

Mar 2, 2018·Scientific Reports·Lara ConsoleCesare Indiveri
Nov 27, 2019·Expert Opinion on Drug Delivery·Chunhua Yang, Didier Merlin
Nov 13, 2019·Pediatric Surgery International·Hiromu MiyakeAgostino Pierro
Aug 24, 2019·Journal of Hematology & Oncology·Xinyu TianShengjun Wang
Jan 17, 2017·International Journal of Cancer. Journal International Du Cancer·Brunna Dos Anjos PultzMarcelo José Barbosa Silva
Jul 19, 2019·Frontiers in Immunology·Huiting ZhangDapeng Chen
Aug 22, 2017·Digestive Diseases and Sciences·Pablo M LinaresMaría-Encarnación Fernández-Contreras
Dec 20, 2018·Frontiers in Immunology·Min LiShengjun Wang
Dec 12, 2018·Journal of Cellular Physiology·Kaveh BaghaeiSeyed Mahmoud Hashemi
Sep 24, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kyriaki BakirtziCharalabos Pothoulakis
Apr 16, 2019·Frontiers in Immunology·Runda WuJunbo Ge
Nov 22, 2019·Frontiers in Immunology·Ruibing YangXi Sun
Jun 6, 2020·Frontiers in Immunology·Tomasz M GrzywaJakub Golab
Dec 31, 2019·Journal of Immunology Research·Qingdong Guan
May 16, 2020·Biological Reviews of the Cambridge Philosophical Society·Dickson K W OcanseyFei Mao
May 28, 2019·Frontiers in Immunology·Francesca Maria ConsonniAntonio Sica
Jun 4, 2020·Cellular Oncology (Dordrecht)·Łukasz ZadkaPiotr Dzięgiel
Feb 23, 2019·Frontiers in Immunology·Yungang WangShengjun Wang
May 23, 2018·Inflammatory Bowel Diseases·Mingzhen Zhang, Didier Merlin
Aug 4, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Mohammad H RashidAli S Arbab
Nov 3, 2020·Frontiers in Immunology·Elham SafarzadehBehzad Baradaran
Dec 18, 2020·Frontiers in Immunology·Farideh OrdikhaniJordi Ochando
Mar 7, 2021·International Journal of Molecular Sciences·Natalia Diaz-GarridoLaura Baldomà
Mar 9, 2021·Frontiers in Bioengineering and Biotechnology·Huailan WangSifeng Tao
Apr 29, 2020·Current Drug Targets·Haichao WangXiaolei Wang
Mar 17, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Na ZhaoTao Wang
May 14, 2021·Cellular Immunology·Hadas Ashkenazi-PreiserMichal Baniyash

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Methods Mentioned

BETA
ELISA
ELISAs
enzyme-linked immunosorbent assay
protein assay
flow cytometry
transmission electron microscopy
electrophoresis
Assay

Software Mentioned

SPSS

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