Abstract
Homosapien collagen beta (1-O) galactosyl transferase 2 (COLGALT2) is an important enzyme during collagen glycosylation, yet its biological functions in cancer are incompletely understood. Our previous study revealed that in the osteosarcoma microenvironment, adipose-derived mesenchymal stem cells (ADSCs) demonstrate cancer-promoting effects, but the exact mechanisms remain unclear. The aim of this study was to investigate the role of COLGALT2 in the osteosarcoma-fostering effects of ADSCs. In this study, we compared COLGALT2 expression between primary and metastatic osteosarcoma tissues and found that metastatic tissues expressed significantly higher COLGALT2 levels. Then, we isolated and identified exosomes secreted by ADSCs. Additionally, we assessed the roles of ADSC exosomes and COLGALT2 in the osteosarcoma-promoting effects of ADSCs. Our results showed that ADSC exosomes could foster the invasion, migration, and proliferation of osteosarcoma cells, together with increasing COLGALT2 expression. COLGALT2 inhibition in MG63 cells suppressed the ADSC exosome-mediated fostering of osteosarcoma cell invasion, migration and proliferation in vitro. Conversely, COLGALT2 overexpression promoted U-2OS cell invasion, migration and pr...Continue Reading
References
Dec 17, 2008·Molecular and Cellular Biology·Belinda ScheggThierry Hennet
Sep 10, 2009·American Journal of Physiology. Endocrinology and Metabolism·Roberto VettorGiovanni Federspil
May 18, 2010·BMC Cell Biology·Jolanda Mp LiefhebberHans C van Leeuwen
Jun 15, 2010·PloS One·Pierre PerrotFrançois Gouin
Jul 2, 2010·Glycobiology·Joana Tavares de OliveiraEmerson Soares Bernardes
Oct 4, 2014·Oncotarget·Gloria BonuccelliNicola Baldini
Jan 13, 2015·Oncology Reports·Sheen-Woo LeeSandip Biswal
May 6, 2015·Hormone Molecular Biology and Clinical Investigation·Guido Lastra, Camila Manrique
Nov 29, 2015·The Orthopedic Clinics of North America·Megan E Anderson
Feb 26, 2016·Plastic and Reconstructive Surgery·Indranil Sinha, Dennis P Orgill
Jul 13, 2016·The Journal of Biological Chemistry·Stephan Baumann, Thierry Hennet
Jan 20, 2017·Cell Death & Disease·Francesca PainoVirginia Tirino
Apr 21, 2017·Oncotarget·Yan WangBohua Chen
Apr 22, 2017·Bioscience Reports·Julie A WebsterChen Chen
Jun 7, 2018·NPJ Precision Oncology·Wenjing ChenXia Liu
Aug 11, 2018·Cytotherapy·Romain GuihoFrançoise Redini
Dec 1, 2018·BMC Cancer·María CollantesIván Peñuelas
Feb 20, 2019·International Journal of Molecular Sciences·Catarina Roma-RodriguesAlexandra R Fernandes
Mar 2, 2019·Current Opinion in Structural Biology·Thierry Hennet
Mar 3, 2019·Molecular Cancer·Irene Li, Barzin Y Nabet
Mar 13, 2019·Molecular Cancer·Yaxin GuoZhenqiang Sun
Mar 21, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Xinhua LiuHuie Jiang
Citations
Feb 11, 2021·OncoTargets and Therapy·Fujiang LiZhong Jiang
Dec 20, 2020·Cancers·Stephanie AnnettTracy Robson
Feb 20, 2021·PloS One·Sook-Kyoung HeoJae-Cheol Jo
Mar 31, 2021·Clinical and Translational Medicine·Ting GuoCongjian Xu
Apr 5, 2021·Biochemical and Biophysical Research Communications·Dandan WeiShiqing Jiang
Apr 19, 2021·Metabolism: Clinical and Experimental·Junru YangHongshan Wei
May 14, 2021·Stem Cell Reviews and Reports·Kun LiuXinwu Lu
Jul 3, 2021·Bioengineering·Banani KunduSubhas C Kundu
Jun 17, 2021·Open Life Sciences·Junguo WangXiaoyun Qian
Jul 15, 2021·Journal of Bone Oncology·Xingyu ChangJingjing Yang
Sep 19, 2021·Journal of Nanobiotechnology·Shenglong Li
Oct 29, 2021·Adipocyte·Rui ZhaoWeijun Pang
Nov 18, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yan LiYi-Hao Wang