Exosomes take (germinal) center stage.

EMBO Reports
Jennifer Pérez-Boza, Dirk M Pegtel

Abstract

Efficient antibody production is a crucial step during immune responses leading to pathogen clearance and neutralization. Immune synapses, contact points between T and B lymphocytes in the presence of an antigen, are necessary to initiate the proliferation and differentiation of B cells in the germinal center. In this issue of EMBO Reports, Fernández-Messina et al [1] present evidence of microRNA transfer from T to B cells via exosomes during synapse formation and highlight the crucial role of these exosomes for germinal center formation and the efficient production of antigen-specific antibodies.

References

Jan 31, 2006·Nature Immunology·Morgan HuseMark M Davis
Mar 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·D Michiel PegtelJaap M Middeldorp
Apr 21, 2011·Nature Communications·María MittelbrunnFrancisco Sánchez-Madrid
Feb 6, 2013·The Journal of Experimental Medicine·Yelena BronevetskyK Mark Ansel
Oct 30, 2016·Trends in Immunology·Balthasar A HeestersMichael C Carroll
Jun 22, 2019·Annual Review of Biochemistry·D Michiel Pegtel, Stephen J Gould
Jan 17, 2020·EMBO Reports·Jeremy Sugarman, Annelien L Bredenoord
Feb 20, 2020·EMBO Reports·Lola Fernández-MessinaFrancisco Sánchez-Madrid

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Citations

Apr 30, 2020·EMBO Reports·Laura Tovini, Sarah E McClelland

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