Expandable right ventricular-to-pulmonary artery conduit: an animal study

Pediatric Research
Younes BoudjemlinePhilipp Bonhoeffer

Abstract

This study was performed to assess a new vascular stent graft as an expandable valved conduit for right ventricular outflow tract (RVOT) reconstruction in sheep. Conduits were constructed by sewing an 18-mm valved conduit inside a stent. Crimped to 16 mm, they were implanted either under or without extracorporeal circulation in seven (group A) and in five (group B) sheep, respectively. Six weeks and 3 mo after their insertion, conduits were dilated intraluminally. A valved stent was implanted percutaneously into conduits before they were killed. Two animals from group A recovered normally, whereas five animals had a complicated postoperative course. In group B, one died acutely due to kinking of the conduit. Balloon dilatations were performed in all surviving animals. First dilatations had a slight impact on valvular function in all animals but one, whereas second dilatations led to significant PR in all. Transcatheter valve implantation was performed successfully. When animals were killed, no bleeding was found around the surgically implanted device. In conclusion, we designed a biologic valved conduit for RVOT reconstruction that can be dilated sequentially to follow animal growth. This new device can have tremendous applicat...Continue Reading

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Citations

Mar 15, 2008·Cardiology in the Young·Philipp Lurz, Philipp Bonhoeffer
Oct 27, 2012·Scandinavian Cardiovascular Journal : SCJ·Daniel WendtMatthias Thielmann
Dec 25, 2013·The Canadian Journal of Cardiology·William WilsonEric Horlick
Jun 29, 2014·Archives of Cardiovascular Diseases·Younes BoudjemlineSébastien Gerelli
Mar 27, 2009·Coronary Artery Disease·Alessandra FrigiolaPhilipp Bonhoeffer
Jul 21, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Anthony AzakieRichard W Bianco
Aug 15, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Anthony AzakieRichard W Bianco
Apr 11, 2018·F1000Research·Sok-Leng Kang, Lee Benson

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