Expanded autologous regulatory T-lymphocyte infusions in ALS: A phase I, first-in-human study

Neurology. Neuroimmunology and Neuroinflammation
Jason R ThonhoffStanley H Appel

Abstract

To determine whether autologous infusions of expanded regulatory T lymphoctyes (Tregs) into patients with amyotrophic lateral sclerosis (ALS) are safe and tolerable during early and later stages of disease. Three patients with ALS, with no family history of ALS, were selected based on their differing sites of disease onset and rates of progression. Patients underwent leukapheresis, and Tregs were subsequently isolated and expanded ex vivo. Tregs (1 × 106 cells/kg) were administered IV at early stages (4 doses over 2 months) and later stages (4 doses over 4 months) of disease. Concomitant interleukin-2 (2 × 105 IU/m2/injection) was administered subcutaneously 3 times weekly over the entire study period. Patients were closely monitored for adverse effects and changes in disease progression rates. Treg numbers and suppressive function were assayed during and following each round of Treg infusions. Infusions of Tregs were safe and well tolerated in all patients. Treg numbers and suppressive function increased after each infusion. The infusions slowed progression rates during early and later stages of disease. Spearman correlation analyses showed that increased Treg suppressive function correlated with slowing of disease progression...Continue Reading

Associated Clinical Trials

Aug 14, 2019·Jason R. Thonhoff

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Citations

Jul 27, 2018·Current Opinion in Neurology·Jason R ThonhoffStanley H Appel
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Methods Mentioned

BETA
Leukapheresis
flow cytometry

Clinical Trials Mentioned

NCT03241784

Software Mentioned

GraphPad Prism

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

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