Expanding analytical options in sports drug testing: Mass spectrometric detection of prohibited substances in exhaled breath

Rapid Communications in Mass Spectrometry : RCM
Mario ThevisWilhelm Schänzer

Abstract

Continuously refining and advancing the strategies and methods employed in sports drug testing is critical for efficient doping controls. Besides improving and expanding the spectrum of target analytes, alternative test matrices have warranted in-depth evaluation as they commonly allow for minimal-/non-invasive and non-intrusive sample collection. In this study, the potential of exhaled breath (EB) as doping control specimen was assessed. EB collection devices employing a non-woven electret-based air filter unit were used to generate test specimens, simulating a potential future application in doping controls. A multi-analyte sports drug testing approach configured for a subset of 12 model compounds that represent specific classes of substances prohibited in sports (anabolic agents, hormone and metabolic modulators, stimulants, and beta-blockers) was established using unispray liquid chromatography/tandem mass spectrometry (LC/MS/MS) and applied to spiked and elimination study EB samples. The test method was characterized concerning specificity, assay imprecision, and limits of detection. The EB collection device allowed for retaining and extracting all selected model compounds from the EB aerosol. Following elution and concent...Continue Reading

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Apr 26, 2017·Rapid Communications in Mass Spectrometry : RCM·Mario ThevisWilhelm Schänzer

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Citations

Feb 15, 2018·Journal of Breath Research·Sabina SeferajOlof Beck
Mar 27, 2018·Drug Testing and Analysis·Michel ArvidssonOlof Beck
Mar 31, 2019·Drug Testing and Analysis·Ann-Marie GarzinskyMario Thevis
May 1, 2019·Traffic Injury Prevention·Olof BeckRobert Kronstrand
Jul 28, 2019·Journal of Breath Research·Eva BorrasCristina E Davis
Nov 18, 2017·Drug Testing and Analysis·Mario ThevisHans Geyer
Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Sep 4, 2020·Rapid Communications in Mass Spectrometry : RCM·Ann-Marie GarzinskyMario Thevis

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