Abstract
The US National Viral Hepatitis Action Plan depends on additional providers to expand hepatitis C virus (HCV) treatment capacity in order to achieve elimination goals. Clinical pharmacists manage treatment and medication within interdisciplinary teams. The study's objective was to determine sustained virologic response (SVR) rates for clinical pharmacist-delivered HCV therapy in an open medical system. Investigators conducted a multicenter retrospective cohort study of patients initiating direct-acting antivirals from January 1, 2014, through March 12, 2018. Data included demographics, comorbidities, treatment, and clinical outcomes. The primary outcome of SVR was determined for patients initiating (intent-to-treat) and those who completed (per-protocol) treatment. Chi-square tests were conducted to identify associations between SVR and adverse reactions, drug-drug interactions, and adherence. A total of 1253 patients initiated treatment; 95 were lost to follow-up, and 24 discontinued therapy. SVR rates were 95.1% (1079/1134) per protocol and 86.1% (1079/1253) intent to treat. The mean age (SD) was 57.4 (10.1) years, the mean body mass index (SD) was 28.7 (6.2) kg/m2, 63.9% were male, 53.7% were black, 40.3% were cirrhotic, 88....Continue Reading
References
Aug 30, 2008·Pharmacotherapy·Jason P Smith
Oct 22, 2008·Journal of Biomedical Informatics·Paul A HarrisJose G Conde
Jun 6, 2009·Journal of Managed Care Pharmacy : JMCP·Nafesa Walters-Smith, S Marshall Marshall
Jul 8, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sanjeev AroraWesley Pak
Dec 15, 2010·Journal of Hepatology·Heidi Barth
Nov 5, 2011·Journal of Managed Care Pharmacy : JMCP·Linda M Spooner
Jul 6, 2014·PloS One·Baligh R YehiaVincent Lo Re
Nov 2, 2014·Pharmacotherapy·Rima A Mohammad GI Liver Nutrition and Infectious Diseases Practice and Research Networks of the American College of Clinical Pharmacy
Jul 3, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eric WenzlerLarry H Danziger
Feb 6, 2016·Pharmacotherapy·Paulina DemingSuzanne B Wortman
Mar 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kathleen N LyScott D Holmberg
Apr 12, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Vincent Lo ReJay R Kostman
Apr 30, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Phoebe Sebhatu, Michelle T Martin
May 14, 2016·MMWR. Morbidity and Mortality Weekly Report·Jorge MeraJohn W Ward
Feb 24, 2017·Journal of Managed Care & Specialty Pharmacy·Sendra YangJamie N Brown
Mar 23, 2017·World Journal of Gastroenterology : WJG·Jacob A LangnessJennifer J Kiser
Jul 1, 2017·Quality Management in Health Care·Emily E DunnT Joseph Mattingly
Aug 9, 2017·Annals of Internal Medicine·Sarah KattakuzhyUNKNOWN ASCEND Providers
Aug 12, 2017·The International Journal on Drug Policy·Sahar BajisJason Grebely
Oct 4, 2017·Annals of Internal Medicine·Pamela S BelperioDavid Shulkin
Mar 27, 2018·The Annals of Pharmacotherapy·Andreina A OttmanRachel B Britt
Mar 31, 2018·The New England Journal of Medicine·T Jake Liang, John W Ward
May 21, 2018·Infectious Disease Clinics of North America·Pamela S BelperioLisa I Backus
May 23, 2018·Journal of Pharmacy Practice·Lena A MikolasScott E Mambourg
Jun 19, 2018·PloS One·Autumn ZuckermanCody Chastain
Sep 15, 2018·Integrated Pharmacy Research & Practice·Antonio OleaParya Saberi
Citations
Mar 4, 2020·Medicina·Vincenzo ScaglioneCarlo Torti
Sep 3, 2020·World Journal of Gastroenterology : WJG·Fuad HasanJeffrey V Lazarus
Jan 20, 2021·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Anita YangJane Giang
Dec 29, 2020·Frontiers in Pharmacology·Nadia A NabulsiTodd A Lee
Nov 10, 2020·Hepatology Communications·Kelly L Hayward, Rianne A Weersink
Mar 8, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Rebekah H AnguianoUdobi Campbell
Jun 12, 2020·The Lancet. Gastroenterology & Hepatology·Amanda J Wade
May 25, 2021·The Mental Health Clinician·Sabrina LivezeyAutumn D Zuckerman
Nov 7, 2020·Research in Social & Administrative Pharmacy : RSAP·Irene Park UlrichBenjamin Gilmer
Aug 14, 2021·Addiction Science & Clinical Practice·Judith I TsuiEmily C Williams
Oct 13, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jennifer LoucksAmy Alonzo