Expanding Hepatitis C Virus Care and Cure: National Experience Using a Clinical Pharmacist-Driven Model

Open Forum Infectious Diseases
David E KorenMichelle T Martin

Abstract

The US National Viral Hepatitis Action Plan depends on additional providers to expand hepatitis C virus (HCV) treatment capacity in order to achieve elimination goals. Clinical pharmacists manage treatment and medication within interdisciplinary teams. The study's objective was to determine sustained virologic response (SVR) rates for clinical pharmacist-delivered HCV therapy in an open medical system. Investigators conducted a multicenter retrospective cohort study of patients initiating direct-acting antivirals from January 1, 2014, through March 12, 2018. Data included demographics, comorbidities, treatment, and clinical outcomes. The primary outcome of SVR was determined for patients initiating (intent-to-treat) and those who completed (per-protocol) treatment. Chi-square tests were conducted to identify associations between SVR and adverse reactions, drug-drug interactions, and adherence. A total of 1253 patients initiated treatment; 95 were lost to follow-up, and 24 discontinued therapy. SVR rates were 95.1% (1079/1134) per protocol and 86.1% (1079/1253) intent to treat. The mean age (SD) was 57.4 (10.1) years, the mean body mass index (SD) was 28.7 (6.2) kg/m2, 63.9% were male, 53.7% were black, 40.3% were cirrhotic, 88....Continue Reading

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Citations

Sep 3, 2020·World Journal of Gastroenterology : WJG·Fuad HasanJeffrey V Lazarus
Jan 20, 2021·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Anita YangJane Giang
Nov 10, 2020·Hepatology Communications·Kelly L Hayward, Rianne A Weersink
Mar 8, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Rebekah H AnguianoUdobi Campbell
Jun 12, 2020·The Lancet. Gastroenterology & Hepatology·Amanda J Wade
May 25, 2021·The Mental Health Clinician·Sabrina LivezeyAutumn D Zuckerman
Nov 7, 2020·Research in Social & Administrative Pharmacy : RSAP·Irene Park UlrichBenjamin Gilmer
Oct 13, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jennifer LoucksAmy Alonzo

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Methods Mentioned

BETA
blood draw

Software Mentioned

SAS
REDCap

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