Expanding the antimalarial toolkit: Targeting host-parasite interactions

The Journal of Experimental Medicine
Jean Langhorne, Patrick E Duffy

Abstract

Recent successes in malaria control are threatened by drug-resistant Plasmodium parasites and insecticide-resistant Anopheles mosquitoes, and first generation vaccines offer only partial protection. New research approaches have highlighted host as well as parasite molecules or pathways that could be targeted for interventions. In this study, we discuss host-parasite interactions at the different stages of the Plasmodium life cycle within the mammalian host and the potential for therapeutics that prevent parasite migration, invasion, intracellular growth, or egress from host cells, as well as parasite-induced pathology.

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Citations

Mar 25, 2016·FEBS Letters·Friedrich Frischknecht, Oliver T Fackler
Jan 8, 2017·Annual Review of Pharmacology and Toxicology·Michael R Yeaman, John P Hennessey
Jan 16, 2018·Nature Reviews. Immunology·Cevayir CobanKen J Ishii
Sep 2, 2019·Parasitology Research·Sarah HendrickxL Maes
Jun 3, 2017·Frontiers in Microbiology·Pragyan AcharyaK D Raja
May 19, 2018·PLoS Pathogens·Dora PosfaiEmily R Derbyshire
Dec 20, 2019·JCI Insight·Iset Medina VeraLiliana Mancio-Silva
May 11, 2017·Bioscience Reports·Sarah K WoollerFrances M G Pearl
Apr 24, 2018·Journal of Immunology Research·Klaudia Łukasiewicz, Marek Fol
Sep 15, 2019·International Immunopharmacology·Guang ChenYa-Ming Cao
Jan 29, 2021·Wellcome Open Research·Franziska HentzschelMatthias Marti

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Methods Mentioned

BETA
phage display

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