Expanding the Application and Formulation Space of Amorphous Solid Dispersions with KinetiSol®: a Review

AAPS PharmSciTech
Daniel J EllenbergerRobert O Williams

Abstract

Due to the high number of poorly soluble drugs in the development pipeline, novel processes for delivery of these challenging molecules are increasingly in demand. One such emerging method is KinetiSol, which utilizes high shear to produce amorphous solid dispersions. The process has been shown to be amenable to difficult to process active pharmaceutical ingredients with high melting points, poor organic solubility, or sensitivity to heat degradation. Additionally, the process enables classes of polymers not conventionally processable due to their high molecular weight and/or poor organic solubility. Beyond these advantages, the KinetiSol process shows promise with other applications, such as the production of amorphous mucoadhesive dispersions for delivery of compounds that would also benefit from permeability enhancement.

References

May 20, 1999·International Journal of Pharmaceutics·R CavalliM R Gasco
Jun 7, 2000·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C Leuner, J Dressman
Jul 18, 2000·Journal of Pharmaceutical and Biomedical Analysis·C RustichelliS Tommasini
Feb 13, 2001·International Journal of Pharmaceutics·S L RaghavanJ Hadgraft
Feb 13, 2001·Journal of Pharmaceutical Sciences·N Jain, S H Yalkowsky
Mar 29, 2001·Journal of Pharmacological and Toxicological Methods·C A Lipinski
Jun 28, 2002·The Annals of Pharmacotherapy·Amanda H CorbettAngela D M Kashuba
May 17, 2003·Ophthalmology·Arun D Singh, Allan Topham
Aug 2, 2003·Drug Development and Industrial Pharmacy·B RambaliD L Massart
Apr 6, 2005·The Journal of Pharmacy and Pharmacology·Piyush Gupta, Arvind K Bansal
Jun 11, 2005·Pharmaceutical Research·Anshuman A AmbikeAnant Paradkar
Aug 18, 2005·Biochemical and Biophysical Research Communications·Changyi ChenQizhi Yao
Dec 20, 2005·Journal of Microencapsulation·E B Souto, R H Müller
Jan 18, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jun-ichi JinnoToshikiro Kimura
Feb 8, 2006·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Sengodan Gurusamy Vijaya Kumar, Dina Nath Mishra
Mar 21, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nobuyuki TanakaToshikiro Kimura
Sep 9, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mamoru FukudaJames W McGinity
Dec 22, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Payam Zahedi, Ping I Lee
May 26, 2007·International Journal of Pharmaceutics·Caroline BruceJames W McGinity
Aug 19, 2007·Pharmaceutical Research·Srinivas BasavojuSitaram P Velaga
Sep 25, 2007·Drug Development and Industrial Pharmacy·Michael M CrowleyCharles Martin
Oct 27, 2007·Drug Development and Industrial Pharmacy·Michael A RepkaJames W McGinity
Dec 7, 2007·Drug Discovery Today·Teófilo VasconcelosPaulo Costa
Jan 1, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Gavin P AndrewsJames W McGinity
Mar 22, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Phillip KrügerMona Abdel-Tawab
Jul 9, 2008·Drug Development and Industrial Pharmacy·Dave A MillerRobert O Williams
Jul 10, 2008·Drug Development and Industrial Pharmacy·Amir Bashiri-ShahroodiRóbert Rajkó
Nov 18, 2008·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Phillip KrügerMona Abdel-Tawab
Dec 2, 2008·Molecular Pharmaceutics·Dwayne T FriesenJ A S Nightingale
May 13, 2009·Molecular Pharmaceutics·Deliang ZhouEric A Schmitt
Aug 15, 2009·Journal of Pharmaceutical Sciences·James C DiNunzioJames W McGinity
Oct 13, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·James C DinunzioJames W McGinity
Oct 29, 2009·AAPS PharmSciTech·Mowafaq M GhareebMohammed I Noordin
Nov 28, 2009·Expert Opinion on Drug Delivery·Yi ShiLuk Chiu Li
Feb 9, 2010·Critical Reviews in Therapeutic Drug Carrier Systems·Bhupinder SinghO Katare
Mar 17, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·James C DiNunzioJames W McGinity
Mar 26, 2010·Drug Development and Industrial Pharmacy·James C DiNunzioJames W McGinity

❮ Previous
Next ❯

Citations

Jan 18, 2019·Drug Development and Industrial Pharmacy·Scott V JermainRobert O Williams
Sep 29, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Serena BertoniNadia Passerini
Nov 9, 2020·AAPS PharmSciTech·Deck Khong TanAli Nokhodchi
Nov 5, 2019·Biochimica Et Biophysica Acta. Reviews on Cancer·Urvi H GalaRobert O Williams
Nov 17, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Isaïe NyambaBrigitte Evrard
Nov 13, 2020·AAPS PharmSciTech·Daniel A DavisRobert O Williams
Feb 9, 2020·International Journal of Pharmaceutics·Konstantinos KatopodisPanagiotis Barmpalexis
Mar 31, 2021·Advanced Drug Delivery Reviews·Stephen A Thompson, Robert O Williams
May 13, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Urvi H GalaRobert O Bill Williams

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
differential scanning calorimetry
scanning electron microscopy

Software Mentioned

Texture Analyzer
KinetiSol
Onmel

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.