Expanding the armamentarium for the spondyloarthropathies

Arthritis Research & Therapy
P Peloso, Jürgen Braun

Abstract

Ankylosing spondylitis (AS) is a member of the family of spondyloarthropathies, which are inflammatory arthritides largely involving the axial skeleton and commonly accompanied by peripheral arthritis. Genetic factors, particularly the presence of HLA-B27, are major contributors to the susceptibility for AS. Despite some therapeutic advances, the treatment options for patients with AS and related disorders have been limited. Several lines of evidence have led to the hypothesis that patients with AS might benefit from treatment with tumor necrosis factor (TNF). Specifically, TNF concentrations are known to be significantly elevated in the synovium of patients with rheumatoid arthritis (RA), in the inflamed gut of patients with inflammatory bowel disease, and in the inflamed sacroiliac joints of patients with AS. The anti-TNF agents have been shown to be of benefit in, and currently have indications for, RA (etanercept, infliximab, adalimumab), Crohn's disease (infliximab), and psoriatic arthritis (etanercept). Because the spondyloarthropathies share pathogenetic mechanisms with the above-specified disease states, studies have been conducted to evaluate the effectiveness of anti-TNF agents in several disorders, including AS. Data...Continue Reading

References

Sep 15, 1977·The New England Journal of Medicine·E P RadfordP G Smith
Aug 11, 1992·Seminars in Arthritis and Rheumatism·C P Chang, H R Schumacher
Mar 1, 1987·Annals of the Rheumatic Diseases·M ManderW C Dick
Aug 1, 1995·Annals of the Rheumatic Diseases·R J FrançoisE G Bywaters
Feb 1, 1997·Tissue Antigens·S Gonzalez-RocesC López-Larrea
Jan 20, 1998·Arthritis and Rheumatism·J BraunJ Sieper
Jul 17, 1998·British Journal of Rheumatology·R Myllykangas-LuosujärviM Hakala
Jan 19, 1999·Rheumatic Diseases Clinics of North America·J BraunJ Sieper
Jan 19, 1999·Rheumatic Diseases Clinics of North America·C S LauQ Y Zeng
Feb 26, 2000·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·M M Ward
Jul 18, 2000·Scandinavian Journal of Rheumatology·P D Sampaio-BarrosA M Samara
Oct 21, 2000·Archives of Internal Medicine·Z UhrinM M Ward
Jan 5, 2002·Arthritis and Rheumatism·J BrandtJ Braun
Apr 19, 2002·The Journal of Pharmacology and Experimental Therapeutics·Bernie ScallonCarrie Wagner
May 3, 2002·The New England Journal of Medicine·Jennifer D GormanJohn C Davis
Jun 6, 2002·Lancet·Stephen B HanauerUNKNOWN ACCENT I Study Group
Oct 31, 2002·Best Practice & Research. Clinical Rheumatology·J Braun, D van der Heijde
Oct 31, 2002·Best Practice & Research. Clinical Rheumatology·A Boonen, J L Severens

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Citations

Feb 5, 2010·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Richard J LinNadera J Sweiss
Aug 29, 2006·World Journal of Gastroenterology : WJG·Katja S RothfussKlaus R Herrlinger

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Methods Mentioned

BETA
ESR

Software Mentioned

MRI Scoring System for Spinal Inflammation in AS ( ASspiMRI )

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