Expanding the 'central dogma': the regulatory role of nonprotein coding genes and implications for the genetic liability to schizophrenia

Molecular Psychiatry
Diana O PerkinsP Sullivan

Abstract

It is now evident that nonprotein coding RNA (ncRNA) plays a critical role in regulating the timing and rate of protein translation. The potential importance of ncRNAs is suggested by the observation that the complexity of an organism is poorly correlated with its number of protein coding genes, yet highly correlated with its number of ncRNA genes, and that in the human genome only a small fraction (2-3%) of genetic transcripts are actually translated into proteins. In this review, we discuss several examples of known RNA mechanisms for the regulation of protein synthesis. We then discuss the possibility that ncRNA regulation of schizophrenia risk genes may underlie the diverse findings of genetic linkage studies including that protein-altering gene polymorphisms are not generally found in schizophrenia. Thus, inadequate or mistimed expression of a functional protein may occur either due to mutation or other dysfunction of the DNA coding base pair sequence, leading to a dysfunctional protein, or due to post-transcriptional events such as abnormal ncRNA regulation of a normal gene. One or more 'schizophrenia disease genes' may turn out to include abnormal transcriptional units that code for RNA regulators of protein coding gene ...Continue Reading

References

Jan 1, 1993·Schizophrenia Bulletin·J A Lieberman, A R Koreen
Jul 25, 1997·American Journal of Medical Genetics·T SasakiS Nanko
Dec 3, 1999·American Journal of Medical Genetics·T H WassinkN C Andreasen
May 17, 2000·American Journal of Medical Genetics·A G Cardno, I I Gottesman
Dec 21, 2000·Current Psychiatry Reports·J Kelly, R M Murray
Apr 24, 2001·The British Journal of Psychiatry. Supplement·B Cooper
May 10, 2001·Schizophrenia Research·C VirgosE Vilella
Jun 1, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·P C AsheA A Boulton
Jul 27, 2001·Human Molecular Genetics·J EkelundL Peltonen
Oct 12, 2001·Schizophrenia Research·N DuranyJ Thome
Nov 20, 2001·EMBO Reports·J S Mattick
Dec 6, 2001·Nature Reviews. Genetics·S R Eddy
Dec 18, 2001·Journal of Neuroscience Research·J S Malter
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hui LiuMaria Karayiorgou
May 3, 2002·Molecular Psychiatry·J A Badner, E S Gershon
May 4, 2002·Nature Reviews. Genetics·Holly K TaborRichard M Myers
May 23, 2002·Human Molecular Genetics·Rosanna WeksbergJeremy Squire
Aug 17, 2002·Current Opinion in Plant Biology·Olivier Voinnet
Sep 11, 2002·Clinical Genetics·S M SinghR O'Reilly
Nov 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Dec 5, 2002·Neurochemical Research·Elysia M HollamsPeter J Leedman
Dec 13, 2002·American Journal of Human Genetics·Hreinn StefanssonDavid St Clair
Dec 21, 2002·Science·Donald Kennedy
Dec 21, 2002·Science·Jennifer Couzin
Jan 14, 2003·Seminars in Cell & Developmental Biology·Jörn Walter, Martina Paulsen
Mar 1, 2003·Molecular Psychiatry·P MugliaJ L Kennedy
Mar 8, 2003·Science·Lee P LimDavid P Bartel
Mar 28, 2003·Genes, Chromosomes & Cancer·Anke van den BergSibrand Poppema
Apr 22, 2003·Journal of Cellular Physiology·Annamaria BevilacquaAngelo Nicolin
May 3, 2003·Human Genetics·Nicholas J BrayMichael C O'Donovan
May 13, 2003·Molecular Psychiatry·H-G HwuS F-C Lee
Jun 6, 2003·Current Opinion in Cell Biology·Angela A Andersen, Barbara Panning

❮ Previous
Next ❯

Citations

Aug 27, 2009·Cellular and Molecular Life Sciences : CMLS·José L MorenoJavier González-Maeso
Mar 10, 2009·Acta Neuropathologica·Akihiko NunomuraGeorge Perry
Jul 9, 2010·Nature·Jonathan A HollanderPaul J Kenny
Feb 9, 2005·Molecular Psychiatry·J L RapoportM R C Psych
Sep 8, 2006·BMC Bioinformatics·Wenjie ShuShengqi Wang
Apr 12, 2008·BMC Bioinformatics·Wenjie ShuShengqi Wang
Sep 13, 2007·PloS One·Thomas HansenThomas Werge
Mar 28, 2009·International Journal of Molecular Sciences·Rudy J CastellaniMark A Smith
Jun 7, 2012·Neurotoxicity Research·Akihiko NunomuraGeorge Perry
Jun 2, 2007·Medical & Biological Engineering & Computing·Zhao WangChih-Chuan Liang
Nov 8, 2008·Molekuliarnaia biologiia·E I RogaevA P Grigorenko
Dec 21, 2012·Expert Opinion on Investigational Drugs·Daniela TarditoMaurizio Popoli
Apr 3, 2008·Annals of Medicine·Douglas J Guarnieri, Ralph J DiLeone
Oct 31, 2006·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Florence Thibaut
Aug 17, 2014·Experimental Neurology·Emily Sun, Yanhong Shi
Mar 24, 2010·Brain Research·Anna IacoangeliHenri Tiedge
Aug 21, 2010·Human Mutation·Diego A ForeroJurgen Del-Favero
Mar 30, 2016·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Erlend J BrevikTetyana Zayats
Dec 6, 2005·Brain Research Reviews·Joana Almeida Palha, Ann B Goodman
Feb 22, 2012·Schizophrenia Research·Yu-Chih ShenChia-Hsiang Chen
Jun 6, 2009·The Journal of Veterinary Medical Science·Abdol Hossein RezaeianHiroshi Yasue
Feb 9, 2008·Free Radical Biology & Medicine·Paula I MoreiraGeorge Perry
Oct 2, 2009·The International Journal of Neuropsychopharmacology·Yael Chertkow-DeutsherDorit Ben-Shachar
Oct 24, 2009·The International Journal of Neuropsychopharmacology·Timothy G Dinan
Sep 9, 2006·The International Journal of Neuropsychopharmacology·Clement C ZaiJames L Kennedy
Mar 22, 2014·Frontiers in Cellular Neuroscience·Elisabetta MaffiolettiLuisella Bocchio-Chiavetto
Mar 10, 2006·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Patrick F SullivanCharles M Perou
Jan 24, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Ina GieglingDan Rujescu
May 25, 2011·Molecular Psychiatry·M D Li, A D van der Vaart
Aug 8, 2008·The American Journal of Gastroenterology·Julie A CornishParis P Tekkis
Nov 6, 2014·Experimental and Therapeutic Medicine·Jie WangYuanshuai Huang
May 28, 2020·Frontiers in Psychiatry·Zexuan LiYong Xu
Feb 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Julie C Kiefer

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