Expanding the clinical spectrum of dermal hyperneury: report of nine new cases and a review of the literature

Histopathology
Eleni IeremiaEduardo Calonje

Abstract

Dermal hyperneury is defined as the hypertrophy of small nerves in the dermis. It has been described in a variety of settings. We present a series of nine new cases with a distinctive clinical presentation and review the existing literature. The aim of the study was to summarise the clinical, histopathological and immunohistochemical findings in a case series of dermal hyperneury with unique clinical presentation. Nine cases were identified from the referral practice of one of the authors. Clinical characteristics, including demographic details, were collated. The histopathological features and novel immunohistochemical findings were analysed. Four cases presented with multiple skin lesions. Clinical evaluation revealed no associated syndromic stigmata. The histology in all cases was that of dermal hyperneury. Immunohistochemistry for phosphatase and tensin homologue (PTEN) and RET was supportive of the lack of syndromic association. The presentation of dermal hyperneury with multiple cutaneous lesions and no syndromic associations is distinctive, and no study with PTEN and RET immunohistochemistry has previously been reported. Comparisons with recent reports of multiple non-syndromic mucocutaneous neuromas are discussed.

References

Sep 1, 1991·The Journal of Investigative Dermatology·D R SpringallJ M Polak
Mar 1, 1986·Clinical Genetics·T M StarinkA W Eriksson
Oct 1, 1985·The British Journal of Dermatology·C M Rowland PayneM M Black
Feb 4, 1967·British Medical Journal·O LjungbergW von Studnitz
Nov 1, 1982·The Journal of Investigative Dermatology·R K Winkelmann, J A Carney
Dec 5, 1998·Pathology·G H MasonE Tay
Feb 19, 2000·The American Journal of Surgical Pathology·L RequenaP E LeBoit
Dec 12, 2001·The British Journal of Dermatology·F TruchotH Perrot
Dec 18, 2002·The Journal of Dermatology·H Serhat InalozSerap S Inaloz
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Steve C HuangZhengping Zhuang
May 17, 2006·Archives of Dermatology·Julie V SchafferSeth J Orlow
Aug 22, 2006·Histopathology·E Karamitopoulou-DiamantisI Vajtai
Nov 14, 2006·Journal of the American Academy of Dermatology·Can BaykalK Didem Yazganoglu
Jul 21, 2009·Journal of Cutaneous Pathology·Chris H JokinenZsolt B Argenyi
Feb 2, 2010·Journal of the American Academy of Dermatology·Rachael L Moore, Clifton R White
Nov 10, 2013·The American Journal of Pathology·Victoria Marsh DurbanAlan R Clarke
Nov 26, 2015·Neural Regeneration Research·Yosuke OhtakeShuxin Li
Jan 5, 2017·Clinical and Experimental Dermatology·N WatsonA MacDonald
May 26, 2018·Journal of Cutaneous Pathology·Michael NoparstakSadia Saeed

❮ Previous
Next ❯

Citations

Jul 18, 2021·Clinics in Dermatology·Zlatko MarušićEduardo Calonje

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

© 2021 Meta ULC. All rights reserved