Expanding the clinicopathological spectrum of late cutaneous Lyme borreliosis (acrodermatitis chronica atrophicans [ACA]): A prospective study of 20 culture- and/or polymerase chain reaction (PCR)-documented cases

Journal of the American Academy of Dermatology
Cédric LenormandDan Lipsker

Abstract

The diagnosis of acrodermatitis chronica atrophicans (ACA), the late cutaneous manifestation of Lyme borreliosis, can be challenging. Histologic changes in ACA have been described in a few studies from endemic countries, relying on cases documented by serology only. We sought to reassess the clinicopathological spectrum of ACA in a series of thoroughly documented cases. Patients prospectively included in a national prospective study were selected on the basis of positive culture and/or polymerase chain reaction of a skin biopsy sample. The diagnosis of ACA was confirmed by reviewing the clinical and serologic data. Histopathological samples were carefully reviewed. Twenty patients were included. Unusual clinical features (ie, numerous small violaceous patches and equidistant small spinous papules with background faint erythema) were observed in 2 patients. Histopathological examination revealed a classic plasma cell-rich perivascular and interstitial pattern with telangiectases in 16 of 25 samples, whereas strikingly prominent granuloma annulare-like or lichenoid features were observed in 4 and 2 of 25 cases, respectively, and discrete nonspecific minor changes in 3 of 25 cases. The small number of patients was a limitation. Ge...Continue Reading

References

Feb 1, 1995·Journal of Cutaneous Pathology·J de KoningJ D Elema
May 29, 1998·Acta Dermato-venereologica·E Brehmer-AnderssonE Asbrink
Mar 13, 2009·Dermatology : International Journal for Clinical and Investigative Dermatology·E DucrouxL Thomas
Mar 24, 2009·The British Journal of Dermatology·C LenormandD Lipsker
Dec 18, 2009·Journal of Cutaneous Pathology·Therese ZollingerWerner Kempf
Feb 6, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G StanekJ Gray
Sep 10, 2011·Lancet·Gerold StanekFranc Strle
Jan 26, 2012·Arthritis and Rheumatism·Eve LevyDan Lipsker
Oct 10, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·N HidriM-C Ploy
Nov 14, 2012·The American Journal of Dermatopathology·Shang-Ian TeeLorenzo Cerroni

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Citations

Nov 29, 2016·Expert Review of Molecular Diagnostics·Eva Ružić-Sabljić, Tjaša Cerar
May 10, 2017·The British Journal of Dermatology·O BauvinA-C Bursztejn
May 28, 2020·BMJ : British Medical Journal·Bart Jan KullbergJoppe W Hovius
May 31, 2020·Journal of Cutaneous Pathology·Andrea Saggini, Lorenzo Cerroni
Jun 9, 2020·Frontiers in Cellular and Infection Microbiology·Emilie Talagrand-ReboulCarole Eldin
Nov 21, 2018·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Jesus Alberto Cardenas-de la GarzaOliverio Welsh
Nov 6, 2018·Ticks and Tick-borne Diseases·Vera MaraspinFranc Strle
Jul 2, 2019·Médecine et maladies infectieuses·X GockoUNKNOWN endorsed by the following scientific societies
Nov 15, 2019·Médecine et maladies infectieuses·M VoiteyT Klopfenstein
Nov 20, 2021·The American Journal of Dermatopathology·Scott Christopher Blaszak, Oluwakemi Onajin

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