Expanding the Molecular Spectrum of Secretory Carcinoma of Salivary Glands With a Novel VIM-RET Fusion.

The American Journal of Surgical Pathology
Alena SkálováIlmo Leivo

Abstract

Secretory carcinoma (SC), originally described as mammary analogue SC, is a predominantly low-grade salivary gland neoplasm characterized by a recurrent t(12;15)(p13;q25) translocation, resulting in ETV6-NTRK3 gene fusion. Recently, alternative ETV6-RET, ETV6-MAML3, and ETV6-MET fusions have been found in a subset of SCs lacking the classic ETV6-NTRK3 fusion transcript, but still harboring ETV6 gene rearrangements. Forty-nine cases of SC revealing typical histomorphology and immunoprofile were analyzed by next-generation sequencing using the FusionPlex Solid Tumor kit (ArcherDX). All 49 cases of SC were also tested for ETV6, RET, and NTRK3 break by fluorescence in situ hybridization and for the common ETV6-NTRK3 fusions using reverse transcription polymerase chain reaction. Of the 49 cases studied, 37 (76%) occurred in the parotid gland, 7 (14%) in the submandibular gland, 2 (4%) in the minor salivary glands, and 1 (2%) each in the nasal mucosa, facial skin, and thyroid gland. SCs were diagnosed more frequently in males (27/49 cases; 55%). Patients' age at diagnosis varied from 15 to 80 years, with a mean age of 49.9 years. By molecular analysis, 40 cases (82%) presented the classic ETV6-NTRK3 fusion, whereas 9 cases (18%) reve...Continue Reading

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Citations

Jan 21, 2021·Current Oncology·D Gwyn BebbMing-Sound Tsao
Mar 5, 2021·Head and Neck Pathology·Shankar VenkatMohammed N Islam
Apr 27, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jessica L GeigerPatrick Ha
Apr 21, 2021·Neoplasia : an International Journal for Oncology Research·Sandra N FreibergerNiels J Rupp
Jan 17, 2021·Medical Molecular Morphology·Hiroshi HaradaAkira Kurose
Apr 27, 2021·The American Journal of Surgical Pathology·Marie Csanyi-BastienMarick Laé

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Methods Mentioned

BETA
Assay
SureFISH
dissection
Sections

Software Mentioned

ArcherDX
Archer Analysis

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