Expanding the repertoire of L-DOPA's actions: A comprehensive review of its functional neurochemistry

Progress in Neurobiology
P De DeurwaerdèreMark J Millan


Though a multi-facetted disorder, Parkinson's disease is prototypically characterized by neurodegeneration of nigrostriatal dopaminergic neurons of the substantia nigra pars compacta, leading to a severe disruption of motor function. Accordingly, L-DOPA, the metabolic precursor of dopamine (DA), is well-established as a treatment for the motor deficits of Parkinson's disease despite long-term complications such as dyskinesia and psychiatric side-effects. Paradoxically, however, despite the traditional assumption that L-DOPA is transformed in residual striatal dopaminergic neurons into DA, the mechanism of action of L-DOPA is neither simple nor entirely clear. Herein, focussing on its influence upon extracellular DA and other neuromodulators in intact animals and experimental models of Parkinson's disease, we highlight effects other than striatal generation of DA in the functional profile of L-DOPA. While not excluding a minor role for glial cells, L-DOPA is principally transformed into DA in neurons yet, interestingly, with a more important role for serotonergic than dopaminergic projections. Moreover, in addition to the striatum, L-DOPA evokes marked increases in extracellular DA in frontal cortex, nucleus accumbens, the subth...Continue Reading


Aug 1, 1978·European Journal of Biochemistry·P A Gulliver, K F Tipton
Oct 1, 1976·Pharmacology, Biochemistry, and Behavior·A DolphinC D Marsden
Jan 1, 1976·European Journal of Pharmacology·A DolphinC D Marsden
Jan 1, 1992·Journal of Neural Transmission. General Section·W MaruyamaD Nakahara
Jul 1, 1990·Trends in Neurosciences·M R DeLong
Jan 1, 1991·Physiology & Behavior·J K MiyamotoS Terashima
Feb 5, 1990·Brain Research·G L Snyder, M J Zigmond
Jun 1, 1990·British Journal of Pharmacology·N B MercuriG Bernardi
Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Jan 1, 1987·Gerontology·W Birkmayer, J D Birkmayer

❮ Previous
Next ❯


Dec 16, 2016·ACS Chemical Neuroscience·Philippe De DeurwaerdèreJosé Marco-Contelles
Mar 6, 2017·Progress in Neurobiology·Philippe De DeurwaerdèreGiuseppe Di Giovanni
May 2, 2017·ACS Chemical Neuroscience·Philippe HuotAndrew C McCreary
May 26, 2017·Expert Opinion on Investigational Drugs·Silvia CerriFabio Blandini
Feb 6, 2017·Journal of Neuroscience Methods·Françoise Dellu-HagedornPhilippe De Deurwaerdère
Jun 20, 2017·Journal of Neurochemistry·Jesper F HavelundJan Bert Gramsbergen
Apr 18, 2018·Macromolecular Bioscience·Georgina FabregatCarlos Alemán
Feb 9, 2018·Journal of Neural Transmission·Oscar Solís, Rosario Moratalla
Jun 21, 2018·The European Journal of Neuroscience·Tanuja Bordia, Xiomara A Perez
Aug 18, 2018·The European Journal of Neuroscience·Emma L Lane
Oct 26, 2018·Developmental Neurobiology·Lisa C HiuraAlexander G Ophir
Jul 25, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Laura BoiAnna R Carta
Jan 8, 2020·International Journal of Molecular Sciences·Abdeslam ChagraouiPhilippe De Deurwaerdère
May 24, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Dhruv PatelKalipada Pahan
Sep 29, 2017·Frontiers in Cellular Neuroscience·Cristina MiguelezPhilippe De Deurwaerdère
May 15, 2018·Movement Disorders Clinical Practice·Jared Thomas HinkleGregory M Pontone
Sep 15, 2018·Frontiers in Neuroscience·Fatemeh N Emamzadeh, Andrei Surguchov
Apr 24, 2020·Frontiers in Pharmacology·Elena Paredes-RodriguezCristina Miguelez
Sep 28, 2018·Molecular Neurobiology·José-Rubén García-MontesRosario Moratalla
Jun 27, 2020·Fortschritte der Neurologie-Psychiatrie·Dirk WoitallaUllrich Wüllner
Dec 10, 2016·Frontiers in Neuroscience·Giuseppe Di GiovanniPhilippe De Deurwaerdère
Aug 23, 2019·Biomolecules·Claudia CarrariniLaura Bonanni
Jan 3, 2021·Brain Research Bulletin·Cheng-Lu ZhangYu-He Yuan
May 29, 2020·Fortschritte der Neurologie-Psychiatrie·Wolfgang H JostLars Tönges
Feb 25, 2021·Signal Transduction and Targeted Therapy·Yan WangJian-Dong Jiang
Jan 28, 2019·Neurochemistry International·Abdeslam ChagraouiPhilippe De Deurwaerdère
Jun 21, 2017·Trends in Pharmacological Sciences·Lina Leinartaité, Per Svenningsson
Jul 25, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ahmed M ShehataLamberto Re
Aug 20, 2021·The Journal of Physiology·Marie BoulainLaurent Juvin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal ganglia in Parkinson's disease (MDS)

The basal ganglia is comprised of the neostriatum, the external and internal pallidal segments, the subthalamic nucleus, the substantia nigra pars reticulata, and the pars compacta of the substantia nigra. The basal ganglia circuitry is responsible for the correct execution of voluntary movements and is implicated in Parkinson's disease. Here is the latest research investigating the basal ganglia in Parkinson's disease.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Cell-Type-Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Astrocytes in Parkinson Disease

Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive loss of dopaminergic neurons. Some PD-genes may be associated with astrocyte dysfunction. Discover the latest research on astrocytes in Parkinson's disease here.

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Blood-Brain Barrier Transport in Neurodegeneration

The blood brain barrier is important for regulating the movement of biomolecules in and out of the brain. For example, membrane transporters in the blood brain barrier can be essential for regulating drug movement and dysregulation of these processes may play a role in neurodegeneration. This feed follows the latest research on this topic.

Atypical Parkinsonism (MDS)

Atypical Parkinsonism presents with the same signs and symptoms of Parkinson's disease, but do not respond to typical Parkionson's disease treatment with levodopa. Atypical Parkinsonism is thought to be associated with abnormal protein buildup within brain cells. Here is the latest on Atypical Parkinsonism.

Cell-Type-Specific Viral Vectors (ASM)

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.


Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Cell-Type Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

© 2022 Meta ULC. All rights reserved