Expanding the scope of strained-alkyne chemistry: a protection-deprotection strategy via the formation of a dicobalt-hexacarbonyl complex

Chemical Communications : Chem Comm
Pierangelo GobboMark S Workentin

Abstract

A protection-deprotection strategy for strained alkynes used for bioorthogonal chemistry is reported. A strained alkyne can be protected with dicobalt-octacarbonyl and we demonstrate for the first time that a strained alkyne can be re-formed and isolated under mild reaction conditions for further bioorthogonal reactivity. The protection-deprotection strategy herein reported will expand the versatility of strained alkynes for the preparation of substrates in chemical biology and materials applications.

References

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Citations

Aug 16, 2015·Current Opinion in Chemical Biology·David M Patterson, Jennifer A Prescher
Aug 5, 2015·Organic Letters·Sedef Karabiyikoglu, Craig A Merlic
Mar 8, 2019·Chemical Communications : Chem Comm·Suguru YoshidaTakamitsu Hosoya
Aug 28, 2020·Chemical Communications : Chem Comm·Naoaki MakioSuguru Yoshida
Jan 8, 2021·Organic Letters·Andrew M EisterholdOgnjen Š Miljanić
Mar 5, 2021·Chemical Reviews·Bauke AlbadaFloris van Delft
Sep 6, 2019·Organic Letters·Jannick Meinecke, Ulrich Koert
Jul 25, 2019·Organic Letters·N Arjunreddy MallampudiDebendra K Mohapatra

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