Expansion and divergence of the GH locus between spider monkey and chimpanzee

Gene
Agnès Revol de MendozaHugo Saldaña

Abstract

Growth hormone (GH) has been previously described as showing distinct evolutionary stories between primates and other mammals. A burst of changes and successive amplification events took place in the primate lineage giving rise to a multigene family in the three Anthropoidea lineages. Polymerase chain reaction (PCR) was used to obtain the genes and the intergenic regions comprising the GH loci of the spider monkey (Ateles geoffroyi), a New-World primate, and of the chimpanzee (Pan troglodytes), an ape. The intergenic sequences of both species were screened by hybridization to detect copies of the Alu family, which have been implicated in the formation of the human GH locus. The GH locus of the spider monkey contains at least six GH-related genes, four of them were cloned. Likewise, five short intergenic sequences of approximately 3 kb were amplified and cloned. On the other hand, in the chimpanzee four new placental lactogen (PL) genes as well as four intergenic regions were amplified. Consequently, in this ape, six genes (two GHs, previously obtained, and four PLs) are clustered, separated by intergenic sequences of different lengths (two short ones of about 5 kb, and at least two long ones between 9 and 13 kb). The presence o...Continue Reading

References

Aug 25, 1990·Nucleic Acids Research·D Reséndez-PérezH A Barrera-Saldaña
Dec 5, 1993·Journal of Molecular Biology·B C Cunningham, J A Wells
Jan 1, 1994·Analytical Biochemistry·J HarrisonS J Clark
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·J A Wells
Aug 22, 1997·The Journal of Biological Chemistry·F C Peterson, C L Brooks
Aug 30, 2002·Journal of Molecular Endocrinology·O C Wallis, M Wallis

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Citations

Jun 29, 2005·Journal of Molecular Evolution·O Caryl WallisMichael Wallis
Sep 10, 2005·Reviews in Endocrine & Metabolic Disorders·Joy OsafoCynthia Gates Goodyer
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Zack PapperDerek E Wildman
Jun 2, 2011·Mobile DNA·Keith R Oliver, Wayne K Greene
Feb 1, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Antonio A Pérez-MayaHugo A Barrera-Saldaña
Sep 19, 2008·Human Mutation·Andreas WolfDavid N Cooper
Jul 29, 2006·Gene·Rafael González AlvarezHugo A Barrera Saldaña
Dec 17, 2005·General and Comparative Endocrinology·O Caryl WallisMichael Wallis
Aug 8, 2021·International Journal of Molecular Sciences·Anthony M Carter

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