Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)-infected individuals with a recombinant modified vaccinia virus Ankara/HIV-1 Gag vaccine.

Journal of Virology
L DorrellAndrew J McMichael

Abstract

Affordable therapeutic strategies that induce sustained control of human immunodeficiency virus type 1 (HIV-1) replication and are tailored to the developing world are urgently needed. Since CD8(+) and CD4(+) T cells are crucial to HIV-1 control, stimulation of potent cellular responses by therapeutic vaccination might be exploited to reduce antiretroviral drug exposure. However, therapeutic vaccines tested to date have shown modest immunogenicity. In this study, we performed a comprehensive analysis of the changes in virus-specific CD8(+) and CD4(+) T-cell responses occurring after vaccination of 16 HIV-1-infected individuals with a recombinant modified vaccinia virus Ankara-vectored vaccine expressing the consensus HIV-1 clade A Gag p24/p17 sequences and multiple CD8(+) T-cell epitopes during highly active antiretroviral therapy. We observed significant amplification and broadening of CD8(+) and CD4(+) gamma interferon responses to vaccine-derived epitopes in the vaccinees, without rebound viremia, but not in two unvaccinated controls followed simultaneously. Vaccine-driven CD8(+) T-cell expansions were also detected by tetramer reactivity, predominantly in the CD45RA(-) CCR7(+) or CD45RA(-) CCR7(-) compartments, and persiste...Continue Reading

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Citations

Jan 16, 2007·Cancer Immunology, Immunotherapy : CII·Guang-Yun SongJoshua D I Ellenhorn
Jun 20, 2012·The Journal of Infectious Diseases·Hongbing YangLucy Dorrell
Mar 14, 2013·The Journal of Infectious Diseases·Joseph P CasazzaUNKNOWN VRC 101 Study Team
Oct 4, 2007·PloS One·Sven LétourneauTomás Hanke
Aug 23, 2011·Expert Review of Vaccines·Stephen R Walsh, Raphael Dolin
Nov 7, 2015·European Journal of Immunology·Brigitte Autran
Oct 23, 2008·Vaccine·Thomas C GreenoughUNKNOWN Pediatric AIDS Clinical Trials Group P1059 Team
Apr 28, 2007·Immunology·Arturo Reyes-SandovalStephen M Todryk
Sep 26, 2008·The Journal of Gene Medicine·Melanie AlbrechtGerald Reese
Jun 19, 2013·Immunological Reviews·Elizabeth Miller, Nina Bhardwaj
Jun 19, 2013·Immunological Reviews·Guislaine Carcelain, Brigitte Autran
Nov 3, 2011·Immunology·Sarah C Gilbert
May 29, 2012·Human Vaccines & Immunotherapeutics·Felipe GarcíaTeresa Gallart
Sep 10, 2014·Frontiers in Microbiology·Beatrice O Ondondo
Jul 13, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hongbing YangLucy Dorrell
Feb 7, 2008·Expert Review of Vaccines·Andreas Boberg, Maria Isaguliants
Nov 13, 2015·Journal of the International AIDS Society·Gina M Graziani, Jonathan B Angel
Sep 19, 2014·Clinical and Vaccine Immunology : CVI·Beatrice OndondoTomáš Hanke
Mar 27, 2015·Journal of Virology·Nicola TernetteTomáš Hanke

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