Expansion load: recessive mutations and the role of standing genetic variation

Molecular Ecology
S Peischl, Laurent Excoffier

Abstract

Expanding populations incur a mutation burden - the so-called expansion load. Previous studies of expansion load have focused on codominant mutations. An important consequence of this assumption is that expansion load stems exclusively from the accumulation of new mutations occurring in individuals living at the wave front. Using individual-based simulations, we study here the dynamics of standing genetic variation at the front of expansions, and its consequences on mean fitness if mutations are recessive. We find that deleterious genetic diversity is quickly lost at the front of the expansion, but the loss of deleterious mutations at some loci is compensated by an increase of their frequencies at other loci. The frequency of deleterious homozygotes therefore increases along the expansion axis, whereas the average number of deleterious mutations per individual remains nearly constant across the species range. This reveals two important differences to codominant models: (i) mean fitness at the front of the expansion drops much faster if mutations are recessive, and (ii) mutation load can increase during the expansion even if the total number of deleterious mutations per individual remains constant. We use our model to make predi...Continue Reading

References

Feb 25, 2000·The American Naturalist·Mark Kirkpatrick, Philippe Jarne
Mar 7, 2001·Molecular Biology and Evolution·M PrzeworskiP Andolfatto
Jan 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christopher A EdmondsL Luca Cavalli-Sforza
Nov 11, 2005·Molecular Biology and Evolution·Seraina KlopfsteinLaurent Excoffier
Feb 17, 2006·Nature·Benjamin L PhillipsRichard Shine
Nov 1, 1956·Proceedings of the National Academy of Sciences of the United States of America·N E MortonH J Muller
Jul 20, 2007·Nature Reviews. Genetics·Adam Eyre-Walker, Peter D Keightley
Aug 19, 2007·Molecular Biology and Evolution·Justin M J TravisKarin Johst
Oct 30, 2007·Theoretical Population Biology·Oskar Hallatschek, David R Nelson
Jun 3, 2008·PLoS Genetics·Adam R BoykoCarlos D Bustamante
Feb 13, 2010·Evolution; International Journal of Organic Evolution·Marta SzulkinPatrice David
Jun 30, 2010·Ecology·Benjamin L PhillipsRichard Shine
Nov 26, 2010·Genetics·Aneil F Agrawal, Michael C Whitlock
Mar 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Richard ShineBenjamin L Phillips
Jan 24, 2012·Genetics·Sankar Subramanian
Mar 1, 2012·Genetics·Montgomery Slatkin, Laurent Excoffier
Apr 6, 2012·PLoS Computational Biology·Rémi LeheLuca Peliti
May 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Lionel RoquesEtienne K Klein
Jun 5, 2012·Genetics·Yann LesecqueAdam Eyre-Walker
Nov 6, 2012·Frontiers in Genetics·Ali TorkamaniNicholas J Schork
Apr 5, 2013·Biology Letters·Eva GraciáAndrés Giménez
Jul 31, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tom LindströmRichard Shine
Oct 10, 2013·Molecular Ecology·S PeischlL Excoffier
Feb 11, 2014·Nature Genetics·Yuval B SimonsGuy Sella
Mar 19, 2014·Trends in Ecology & Evolution·Marc Rius, John A Darling
Aug 27, 2014·Current Opinion in Genetics & Development·Vitor SousaLaurent Excoffier
Sep 11, 2014·Molecular Ecology·Lise-Marie PigneurKarine Van Doninck
Oct 4, 2014·American Journal of Human Genetics·Wenqing FuJoshua M Akey
Dec 3, 2014·Current Opinion in Genetics & Development·Kirk E Lohmueller
Mar 27, 2015·The American Naturalist·Stephan PeischlLaurent Excoffier

❮ Previous
Next ❯

Citations

Feb 15, 2016·Trends in Genetics : TIG·Yaniv Brandvain, Stephen I Wright
Jan 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Rajiv C McCoy, Joshua M Akey
Dec 30, 2015·Proceedings of the National Academy of Sciences of the United States of America·Brenna M HennCarlos D Bustamante
Jan 23, 2016·Molecular Ecology·Loren Rieseberg, Armando Geraldes
Dec 5, 2014·Molecular Ecology·Dan G BockLoren H Rieseberg
Apr 27, 2016·Current Biology : CB·Jacqueline A RobinsonRobert K Wayne
Sep 1, 2015·PLoS Genetics·Daniel J BalickShamil R Sunyaev
Jun 17, 2016·Ecology Letters·Matti GralkaOskar Hallatschek
Sep 2, 2016·Current Opinion in Genetics & Development·Stephan PeischlLaurent Excoffier
Nov 13, 2015·Molecular Ecology·Vedran BožičevićAndreas Wollstein
Mar 28, 2017·Molecular Ecology·Katrien VandepitteOlivier Honnay
Jan 19, 2018·Molecular Biology and Evolution·Yvonne WilliJosh Van Buskirk
Sep 29, 2018·PLoS Genetics·Kimberly J GilbertLaurent Excoffier
Oct 23, 2018·PLoS Genetics·Bernard Y KimKirk E Lohmueller
Oct 28, 2018·The New Phytologist·Lotte A van BoheemenKathryn A Hodgins
Nov 2, 2018·Journal of Economic Entomology·Petra FerronatoAlberto Soares Corrêa
Dec 29, 2018·Evolution; International Journal of Organic Evolution·Xin-Sheng HuXiao-Yang Chen
Dec 28, 2018·Molecular Ecology·James W DemastesTheresa A Spradling
May 1, 2019·Anais Da Academia Brasileira De Ciências·Rosana T BragaThiago F Rangel
Jun 5, 2019·American Journal of Botany·Yvonne Willi
Apr 2, 2020·Genome Biology and Evolution·Kohta YoshidaJun Kitano
Jun 20, 2020·Journal of Evolutionary Biology·Francisco Encinas-VisoJohn R Pannell
Sep 30, 2020·Biology Letters·Courtney E GormanMarc Stift
Feb 9, 2018·PloS One·Muhammad ShakeelIshtiaq Ahmad Khan
Aug 20, 2019·Molecular Biology and Evolution·Stéphane Aris-Brosou
Jun 17, 2020·Evolution; International Journal of Organic Evolution·Antoine PerrierYvonne Willi
Dec 12, 2018·Bulletin of Mathematical Biology·Cindy Gidoin, Stephan Peischl
Jun 27, 2019·Molecular Biology and Evolution·Lars BosshardLaurent Excoffier
Jun 24, 2020·Nature Ecology & Evolution·David Ben Stern, Carol Eunmi Lee
Oct 6, 2016·Genome Biology and Evolution·Anna FijarczykWieslaw Babik
Dec 12, 2018·BMC Evolutionary Biology·Yiyong ChenAibin Zhan
Jun 19, 2019·Molecular Biology and Evolution·Annabel C BeichmanRobert K Wayne
Sep 9, 2019·Molecular Ecology·Nadège BélouardEric J Petit
Dec 1, 2017·Genetics·Stephan PeischlLaurent Excoffier
Oct 23, 2019·Evolution Letters·Matthew H KoskiLaura F Galloway
Dec 1, 2016·Current Zoology·Frédérique ViardJohn A Darling

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved