Expansion of a unique macrophage subset in rheumatoid arthritis synovial lining layer.

Clinical and Experimental Immunology
M TanakaT Matsuyama

Abstract

The Z39Ig protein (complement receptor for C3b and iC3b) is expressed on resident tissue macrophages in various tissues. This study was undertaken to examine the distribution of Z39Ig+cells and their phenotypic features in rheumatoid arthritis (RA) synovium, in comparison with those of osteoarthritis (OA) and psoriatic arthritis (PsA) synovium. Monoclonal anti-Z39Ig antibody was produced by immunizing Z39Ig transfected murine pre B cells and used for the identification of Z39Ig+cells. Z39Ig+cells were further stained with antibodies to macrophages, fibroblast-like synoviocytes, complement receptors and dendritic cells by using the double immunostaining method in normal, RA, OA and PsA synovium. RA synovial mononuclear cells were double-stained using anti-Z39Ig and anti-CD11c antibodies and sorted into Z39Ig+CD11c+cells and Z39Ig+CD11c-cells. These cell populations were then analysed by electron microscopy. The expression of the Z39Ig protein was limited to intimal macrophages in normal, RA, OA and PsA synovium. The numbers of Z39Ig+CD11c+cells and the ratios of Z39Ig+CD11c+cells to Z39Ig+cells were increased in the synovial lining layer of RA as compared with those of OA and PsA. The ultrastructural analysis of Z39Ig+CD11c+cell...Continue Reading

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Citations

Jul 12, 2011·The American Journal of Pathology·Nick N GorganiAntonio Ferrante
Sep 22, 2018·Chembiochem : a European Journal of Chemical Biology·Hye Jin LeeWeibo Cai
Feb 18, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuefang MaAntonio Ferrante
Jan 11, 2020·Frontiers in Immunology·Usma MunawaraAntonio Ferrante
May 1, 2020·Mediators of Inflammation·Jiajie TuWei Wei
Aug 15, 2017·Canadian Journal of Gastroenterology & Hepatology·Yuki KakinumaYoshifumi Watanabe
Apr 2, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Fang ZhengSteve Schoonooghe

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