Expansion of Fc receptor-bearing T lymphocytes in patients with immunoglobulin G and immunoglobulin A myeloma

The Journal of Clinical Investigation
R G HooverR G Lynch

Abstract

Lymphocytes obtained from the blood of normal individuals and six patients with newly diagnosed multiple myeloma were separated into T and non-T cell populations by rosette-formation with sheep erythrocytes, and were then assayed for the presence of surface membrane Fc receptors. When compared with normal individuals, four patients with IgG myeloma had a three- to fourfold increase in T cells with IgG receptors (T gamma cells) and two patients with IgA myeloma had a two- to threefold increase in T cells with IgA receptors (T alpha cells). Patients with IgG or IgA myeloma had normal numbers of non-T lymphocytes with surface receptors for IgG and IgA, respectively. The finding that human myeloma is accompanied by elevated numbers of T cells with Fc receptors for the heavy chain class of the myeloma protein: (1) may account for the apparent "monoclonal" lymphocyte population in patients with myeloma; (b) extends to humans similar observations made in mice with secretory plasmacytomas; and (c) is of interest because T cells with Fc receptors are immunoregulatory lymphocytes.

References

Sep 1, 1979·The Journal of Clinical Investigation·H L SpiegelbergD A Mathison
Jan 1, 1975·European Journal of Immunology·M FerrariniM L Durante
Jul 1, 1975·Annals of Internal Medicine·N I Abdou, N L Abdou
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·K HannestadH N Eisen

❮ Previous
Next ❯

Citations

Jul 1, 1983·Journal of Clinical Immunology·C D PlatsoucasB D Clarkson
Jul 1, 1993·Journal of Clinical Immunology·M Sandor, R G Lynch
Jan 1, 1984·Folia Microbiologica·L Fornůsek, V Vĕtvicka
Jan 1, 1984·Disease-a-month : DM·J Laurence
Dec 1, 1984·Molecular Immunology·W H FridmanJ Thèze
Dec 1, 1990·Molecular Immunology·J L TeillaudW H Fridman
Mar 1, 1990·The Journal of Experimental Medicine·R C MonteiroM D Cooper
Oct 1, 1981·The Journal of Clinical Investigation·H L Spiegelberg, R A Simon
Jan 1, 1995·The Journal of Clinical Investigation·R G HooverB Barlogie
Jan 1, 1987·International Reviews of Immunology·T J WaldschmidtR G Lynch
Feb 27, 1999·Leukemia & Lymphoma·C MathiotC Sautès
Jul 1, 1995·Leukemia & Lymphoma·M H BakkusK Thielemans
Jan 1, 1997·International Reviews of Immunology·H RouardJ L Teillaud
Mar 1, 1991·Chest·R S McKenzieJ C Goldsmith
Nov 1, 1987·Mayo Clinic Proceedings·P R GreippR A Kyle
Dec 1, 1981·British Journal of Haematology·M M Oken, N E Kay
Feb 1, 1997·Hematology/oncology Clinics of North America·N C Munshi
Aug 1, 1991·Journal of Clinical Pharmacy and Therapeutics·T C HillardM I Whitehead
Feb 28, 2003·Hematological Oncology·M RaitakariD E Joshua
Jul 1, 1991·American Journal of Hematology·M R MacKenzieV Caggiano
Jul 1, 1982·Scandinavian Journal of Haematology·H MellstedtA Ahre
Oct 1, 1982·Scandinavian Journal of Haematology·C P Worman, J C Cawley
Jan 1, 1985·Acta Medica Scandinavica·C P Maury, A M Teppo
Jan 1, 1987·Acta Medica Scandinavica·A Wangel
May 1, 1984·Scandinavian Journal of Haematology·L HammarströmC I Smith
Sep 1, 1990·Blood Reviews·S L Zaknoen, N E Kay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.