PMID: 1200045Nov 15, 1975Paper

Expansion of intravascular volume and fetal outcome in patients with chronic hypertension and pregnancy

American Journal of Obstetrics and Gynecology
F Arias

Abstract

Measurements of blood volume were carried out between 24 and 40 weeks of gestation in 20 multiparous patients with chronic hypertension and pregnancy. Hypertensive patients had both reduced blood volume and infants of smaller weight (p less than 0.01) than nonhypertensive control subjects. There was a significant difference (p less than 0.01) in the degree of blood volume expansion in hypertensive mothers who were delivered of infants who were adequate for gestational age (AGA), term, or premature, compared to those who were delivered of infants who were small for gestational age (SGA) or stillborn. Classification of chronic hypertension during pregnancy according to the American Committee on Maternal Welfare classification or according to severity of the hypertension was of no value in identifying the mothers at risk of delivering intrauterine growth-retarded infants. However, failure in achieving a blood volume expansion of at least 60 c.c. per kilogram clearly identified those pregnancies leading to growth retardation and fetal death. The decrease or lack of intravascular volume expansion was reflected in the presence of creatinine clearance values at nonpregnant levels in the mothers who were delivered of SGA infants and in...Continue Reading

Citations

Jan 1, 1985·Acta Medica Scandinavica. Supplementum·K Rasmussen
Feb 1, 1987·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·C WeitzJ W Johnson
Oct 1, 1986·British Journal of Obstetrics and Gynaecology·G RobertsonR E Robinson
Sep 10, 2002·Obstetrical & Gynecological Survey·Gabriella Pridjian, Jules B Puschett
Aug 1, 1992·The Australian & New Zealand Journal of Obstetrics & Gynaecology·L M McCowan, R P Naden
Jan 1, 1989·Journal of Perinatal Medicine·S Mor-YosefJ G Schenker
Jul 1, 1980·British Journal of Obstetrics and Gynaecology·C J Hutchins
Feb 1, 1979·The Australian & New Zealand Journal of Obstetrics & Gynaecology·W A Walters
Jan 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·I Romslo
Sep 28, 1985·British Medical Journal·M L Chiswick
Jan 1, 1981·Drug Intelligence & Clinical Pharmacy·A L Wilson, G R Matzke
May 14, 2009·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Gerda G ZeemanJack A Pritchard
Jun 1, 1989·British Journal of Obstetrics and Gynaecology·S L Duncan
Feb 1, 1996·British Journal of Obstetrics and Gynaecology·L M McCowanG Gamble
Jan 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·J M Davison
Jul 28, 2004·Clinical Chemistry·Per Magne Ueland, Stein Emil Vollset

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