Expansion of large granular lymphocytes following Pseudomonas infection in a patient with adult-onset Still's disease

Modern Rheumatology
Rie TabataHiroyuki Kotani

Abstract

We report a patient who had a 4-year history of adult-onset Still's disease (AOSD) and showed a prominent increase in large granular lymphocytes (LGL) when she developed severe Pseudomonas conjunctivitis due to Pseudomonas aeruginosa, skin eruptions, liver damage, and abnormal findings in coagulation studies, without any evidence of active viral activation, hemophagocytosis, or malignancies. The increased LGL cells were CD3(+)CD8(+), and disappeared promptly after the administration of antibiotics combined with prednisolone, with subsequent stabilization of her general condition.

References

Jan 1, 1991·Infection·J E Fowler
Mar 1, 1971·Annals of the Rheumatic Diseases·E G Bywaters
May 1, 1993·Infection·Y LermanY L Danon
Jul 9, 2004·International Journal of Hematology·Tsuyoshi Muta, Yujiro Yamano

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Adult-onset Still's disease (AOSD) is a form of Still's disease, a rare systemic autoinflammatory disease characterized by the classic triad of persistent high spiking fevers, joint pain, and a distinctive salmon-colored bumpy rash. Discover the latest research on AOSD here.

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