Expansion of pre-existing, lymph node-localized CD8+ T cells during supervised treatment interruptions in chronic HIV-1 infection

The Journal of Clinical Investigation
M AltfeldB D Walker

Abstract

To date, most studies have focused on the characterization of HIV-1-specific cellular immune responses in the peripheral blood (PB) of infected individuals. Much less is known about the comparative magnitude and breadth of responses in the lymphoid tissue. This study analyzed HIV-1-specific CD8+ T cell responses simultaneously in PB and lymph nodes (LNs) of persons with chronic HIV-1 infection and assessed the dynamics of these responses during antiretroviral treatment and supervised treatment interruption (STI). In untreated chronic infection, the magnitude of epitope-specific CD8+ T cell activity was significantly higher in LNs than in PB. Responses decreased in both compartments during highly active antiretroviral therapy, but this decline was more pronounced in PB. During STI, HIV-1-specific CD8+ T cell responses in PB increased significantly. Enhancement in breadth and magnitude was largely due to the expansion of pre-existing responses in the LNs, with new epitopes infrequently targeted. Taken together, these data demonstrate that HIV-1-specific CD8+ T cells are preferentially located in the LNs, with a subset of responses exclusively detectable in this compartment. Furthermore, the enhanced CD8+ T cell responses observed...Continue Reading

References

Jul 23, 1987·Nature·B D WalkerR T Schooley
Jun 23, 1994·Nature·L L LauR Ahmed
Jun 1, 1993·Seminars in Immunology·G PantaleoA S Fauci
Jan 12, 1999·Nature Medicine·S J BrodieS R Riddell
May 26, 1999·The New England Journal of Medicine·L ZhangD D Ho
May 29, 1999·The New England Journal of Medicine·J LisziewiczF Lori
Oct 12, 2000·Nature·E S RosenbergB D Walker
Apr 20, 2001·Nature·A J McMichael, S L Rowland-Jones
Aug 2, 2001·Nature Medicine·M Altfeld, B D Walker
Nov 1, 2001·Proceedings of the National Academy of Sciences of the United States of America·G M OrtizD F Nixon
Apr 30, 2002·Current Opinion in Infectious Diseases·H J Stellbrink, J van Lunzen

❮ Previous
Next ❯

Citations

Aug 6, 2004·Bulletin of Mathematical Biology·Seema H BajariaDenise E Kirschner
Jun 29, 2002·Current Opinion in Immunology·Rajesh T Gandhi, Bruce D Walker
Aug 30, 2002·Trends in Immunology·Todd M AllenBruce D Walker
Sep 15, 2004·The Journal of Experimental Medicine·Jason M BrenchleyDaniel C Douek
Nov 13, 2004·Clinical and Diagnostic Laboratory Immunology·Michael A Kolber
Apr 29, 2004·Journal of Virology·Koen K A Van RompayNorbert Bischofberger
Jan 5, 2005·PLoS Medicine·Emmanouil PapasavvasLuis J Montaner
Dec 24, 2005·Enfermedades infecciosas y microbiología clínica·Felipe GarcíaPere Domingo
Jul 16, 2008·Seminars in Immunology·Michael M Lederman, Leonid Margolis
Jun 19, 2013·Immunological Reviews·Korey R DemersMichael R Betts
Mar 22, 2005·Journal of Immunological Methods·Chan ZengElizabeth J McFarland
Nov 1, 2017·Frontiers in Immunology·Federico Perdomo-CelisMaría Teresa Rugeles
Aug 27, 2019·Frontiers in Immunology·Federico Perdomo-CelisMaria T Rugeles

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
FCS
density

Software Mentioned

SigmaPlot

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Annals of the New York Academy of Sciences
D I AbramsP A Volberding
The Journal of Immunology : Official Journal of the American Association of Immunologists
Sven-Christian SenskenMarkus H Gräler
© 2022 Meta ULC. All rights reserved