Expansion of the human mitochondrial proteome by intra- and inter-compartmental protein duplication.

Genome Biology
Radek Szklarczyk, Martijn A Huynen

Abstract

Mitochondria are highly complex, membrane-enclosed organelles that are essential to the eukaryotic cell. The experimental elucidation of organellar proteomes combined with the sequencing of complete genomes allows us to trace the evolution of the mitochondrial proteome. We present a systematic analysis of the evolution of mitochondria via gene duplication in the human lineage. The most common duplications are intra-mitochondrial, in which the ancestral gene and the daughter genes encode mitochondrial proteins. These duplications significantly expanded carbohydrate metabolism, the protein import machinery and the calcium regulation of mitochondrial activity. The second most prevalent duplication, inter-compartmental, extended the catalytic as well as the RNA processing repertoire by the novel mitochondrial localization of the protein encoded by one of the daughter genes. Evaluation of the phylogenetic distribution of N-terminal targeting signals suggests a prompt gain of the novel localization after inter-compartmental duplication. Relocalized duplicates are more often expressed in a tissue-specific manner relative to intra-mitochondrial duplicates and mitochondrial proteins in general. In a number of cases, inter-compartmental ...Continue Reading

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Citations

Mar 8, 2011·Molecular Biology and Evolution·Rob M de GraafJohannes H P Hackstein
Sep 7, 2014·Genome Biology and Evolution·Shao-Lun LiuKeith L Adams
Mar 10, 2016·Biochimica Et Biophysica Acta·Michał LaskowskiAdam Szewczyk
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Aug 21, 2012·Biochimica Et Biophysica Acta·Martijn A HuynenRadek Szklarczyk
Apr 3, 2019·Molecular Biology and Evolution·Sbatie LamaOlivier Van Aken
Aug 11, 2020·BMC Evolutionary Biology·Samuel H A von der Dunk, Berend Snel
May 5, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thomas PfannschmidtPedro M Quiros

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Software Mentioned

TreeBeST
BiNGO
PhyML
MitoCarta
TargetP
WUBLASTP
MUSCLE
Target P
Clustal W
MitoProt

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