Expansion of the Liver Donor Supply Through Greater Use of Split-Liver Transplantation: Identifying Optimal Recipients

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Douglas B MogulDorry L Segev

Abstract

The increased use of split-liver transplantation (SLT) represents a strategy to increase the supply of organs. Although outcomes after SLT and whole liver transplantation (WLT) are similar on average among pediatric recipients, we hypothesized that the relationship between graft type and outcomes may vary depending on patient, donor, and surgical characteristics. We evaluated graft survival among pediatric (<18 years) deceased donor, liver-only transplant recipients from March 2002 until December 2015 using data from the Scientific Registry of Transplant Recipients. Graft survival was assessed in a Cox proportional hazards model, with and without effect modification between graft type and donor, recipient, and surgical characteristics, to identify conditions where the risk of graft loss for SLT and WLT were similar. In a traditional multivariable model, characteristics associated with graft loss included donor age >50 years, recipient weight <10 kg, acute hepatic necrosis, autoimmune diseases, tumor, public insurance, and cold ischemia time (CIT) >8 hours. In an analysis that explored whether these characteristics modified the relationship between graft type and graft loss, many characteristics associated with loss actually had...Continue Reading

References

Aug 2, 2002·Transplantation·Sue V McDiarmidUNKNOWN Principal Investigators and Institutions of the Studies of Pediatric Liver Transplantation (SPLIT) Research Group
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S FengR M Merion
Oct 6, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Dorry L SegevPaul J Thuluvath
Jun 14, 2008·Biostatistics·Thomas A Louis, Scott L Zeger
Aug 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Natasha S BeckerJohn A Goss
Apr 19, 2012·The British Journal of Surgery·M MallikG J Pettigrew
May 4, 2013·Journal of the American College of Surgeons·M B Majella DoyleWilliam C Chapman
Aug 28, 2013·Journal of the American College of Surgeons·Ryan P CauleyHeung Bae Kim
Jul 22, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A B MassieD L Segev
Oct 11, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Moustafa Mabrouk MouradM Thamara P R Perera
Oct 6, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Evelyn K Hsu, George V Mazariegos
Jan 5, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W R KimB L Kasiske
Jul 18, 2017·Gastroenterology·Evelyn K HsuJennifer C Lai
Jan 9, 2018·The Journal of Pediatrics·Douglas B MogulDorry L Segev

❮ Previous
Next ❯

Citations

Oct 10, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Wei GaoZhongyang Shen
Nov 11, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jin GeJennifer C Lai
Feb 9, 2021·Transplantation Direct·Adam M ThorneVincent E de Meijer
Oct 16, 2021·Current Opinion in Organ Transplantation·Ngee-Soon LauCarlo Pulitano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Joachim AndrassyEurotransplant Liver Advisory Committee
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
A K MathurRobert M Merion
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
K W LeeRobert A Montgomery
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
S J PelletierH W Sollinger
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Zebin ZhuXiaoshun He
© 2022 Meta ULC. All rights reserved