Expansion of trisomy 8 and Sweet syndrome in a prolonged course of aplastic anemia

Journal of Pediatric Hematology/oncology
Shouichi OhgaToshiro Hara

Abstract

We describe a 17-year-old boy with aplastic anemia who had Sweet syndrome develop with increasing expansion of trisomy 8. The diagnosis of aplastic anemia was made at 6 years of age. Cytopenias partially responded to danazol therapy. Cytogenetic studies of bone marrow (BM) cells were normal until the detection of trisomy 8 at 14 years of age. This clone increased with the progression of cytopenias. Cell sorting and fluorescence in situ hybridization analysis revealed that trisomy 8 was present only in nonlymphoid elements. When the patient was 17 years of age, Sweet syndrome developed. BM study showed myelodysplastic features, in which trisomy 8 occupied 74% of BM cells with additional chromosomal changes. Trisomy 8 may contribute to the late transformation of myeloid lineages in BM failure.

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Citations

May 31, 2003·International Journal of Hematology·Hideki HattoriShotaro Yoneda
Jul 9, 2002·British Journal of Haematology·Shouichi OhgaUNKNOWN Aplastic Anaemia Committee of the Japanese Society of Paediatric Haematology
Aug 20, 2009·Pediatric Dermatology·James Halpern, Asad Salim
Oct 21, 2011·Pediatric Dermatology·Lily C UihleinMarilyn G Liang
Aug 23, 2008·International Journal of Dermatology·Thomas BuckRobert A Schwartz

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