Expansion of unusual CD4+ T cells in severe rheumatoid arthritis

Arthritis and Rheumatism
P B MartensC M Weyand

Abstract

The repertoire of T cells in patients with rheumatoid arthritis (RA) is characterized by clonal expansion of selected CD4+ T cells, which are autoreactive and lack the expression of the functionally important CD28 molecule. The goal of this study was to determine the contribution of these unusual lymphocytes to the disease process. RA patients (n = 108) and normal controls (n = 53) were examined for the expression of CD4+ CD28- T cells by 2-color fluorescence-activated cell sorter analysis. Clinical data were ascertained by retrospective chart review. The frequencies of CD4+ CD28- T cells displayed a bimodal distribution, defining carriers and noncarriers in normal subjects and RA patients. In longitudinal studies, the noncarrier and carrier phenotypes were stable over time. Carriers of CD4+ CD28- T cells accumulated in the RA population (64% versus 45%; P = 0.02). The expansion of CD4+ CD28- T cells correlated with extraarticular involvement, but not with disease duration, antirheumatic treatment, or severity of joint destruction. The patient subsets with nodular disease (P = 0.02) and rheumatoid organ disease (P = 0.04) had the highest proportion of CD4+ CD28- T cell carriers. The size of the CD4+ CD28- compartment correlated...Continue Reading

References

Sep 11, 1975·The New England Journal of Medicine·J A Van Boxel, S A Paget
Aug 1, 1992·The Journal of Clinical Investigation·W V WilliamsD B Weiner
Nov 15, 1992·Annals of Internal Medicine·C M WeyandJ J Goronzy
Jun 1, 1992·The Journal of Clinical Investigation·C M WeyandJ J Goronzy
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M D HowellS W Brostoff
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·I StamenkovicJ T Kurnick
May 20, 1988·Science·J A ToddL Steinman
Jan 1, 1994·Advances in Immunology·R Winchester
Jun 1, 1995·Current Opinion in Immunology·D L Mueller, M K Jenkins
May 1, 1995·The Journal of Clinical Investigation·C M WeyandJ J Goronzy
Nov 1, 1994·The Journal of Clinical Investigation·J J GoronzyC M Weyand
Apr 1, 1994·Current Opinion in Immunology·P H KrammerK M Debatin
May 1, 1994·Current Opinion in Rheumatology·J J Goronzy, C M Weyand
Jan 1, 1993·Annual Review of Immunology·P S Linsley, J A Ledbetter
May 1, 1996·The Journal of Clinical Investigation·D SchmidtC M Weyand

❮ Previous
Next ❯

Citations

Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·U G WagnerJ J Goronzy
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·K KoetzC M Weyand
Jun 26, 2003·Arthritis Research & Therapy·Andrzej PawlikBarbara Gawronska-Szklarz
Jul 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Veronika GrohThomas Spies
Sep 4, 2003·The Journal of Clinical Investigation·Andrew P FontenotBrian L Kotzin
Oct 7, 2005·Arthritis Research & Therapy·Kenneth J WarringtonCornelia M Weyand
Nov 10, 2005·Arthritis Research & Therapy·Carl TuressonEric L Matteson
Jun 30, 2006·Arthritis Research & Therapy·Carlos Lopez-LarreaJesus Martinez-Borra
Dec 13, 2006·Annals of the Rheumatic Diseases·Lennart T H JacobssonPierre Geborek
Sep 11, 2007·Arthritis Research & Therapy·Andreas E R FasthChristina Trollmo
Oct 20, 2009·Arthritis Research & Therapy·Jörg J Goronzy, Cornelia M Weyand
Dec 18, 2009·Gerontology·Nicolas P AndrewsCornelia M Weyand
Feb 9, 2012·Journal of the Association for Research in Otolaryngology : JARO·Heather K LehmanRichard B Bankert
Dec 31, 2002·Blood·Kenneth J WarringtonJörg J Goronzy
Apr 26, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tongguang WangAvindra Nath
Nov 9, 2000·The Journal of Biological Chemistry·A N VallejoJ J Goronzy
Sep 27, 2002·The Journal of Biological Chemistry·Abbe N VallejoJörg J Goronzy
Jun 13, 2019·Nature Reviews. Immunology·Jörg J Goronzy, Cornelia M Weyand
Nov 19, 2014·Current Opinion in Rheumatology·Ashima MakolKenneth J Warrington
Nov 12, 1998·Arthritis and Rheumatism·F ImamuraK Nishioka
Dec 31, 1998·Arthritis and Rheumatism·T NamekawaC M Weyand
May 18, 1999·Current Opinion in Rheumatology·C M Weyand, J J Goronzy
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T NamekawaJ J Goronzy
Oct 13, 2004·Arthritis and Rheumatism·Carl TuressonEric L Matteson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.