Expansions and contractions in a tandem repeat induced by double-strand break repair.

Molecular and Cellular Biology
F PâquesJames E Haber

Abstract

Repair of a double-strand break (DSB) in yeast can induce very frequent expansions and contractions in a tandem array of 375-bp repeats. These results strongly suggest that DSB repair can be a major source of amplification of tandemly repeated sequences. Most of the DSB repair events are not associated with crossover. Rearrangements appear in 50% of these repaired recipient molecules. In contrast, the donor template nearly always remains unchanged. Among the rare crossover events, similar rearrangements are found. These results cannot readily be explained by the gap repair model of Szostak et al. (J. W. Szostak, T. L. Orr-Weaver, R. J. Rothstein, and F. W. Stahl, Cell 33:25-35, 1983) but can be explained by synthesis-dependent strand annealing (SDSA) models that allow for crossover. Support for SDSA models is provided by a demonstration that a single DSB repair event can use two donor templates located on two different chromosomes.

References

Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S Scherer, R W Davis
Jan 16, 1976·Molecular & General Genetics : MGG·M A Resnick, P Martin
Dec 1, 1992·Current Opinion in Biotechnology·R R Sinden, R D Wells
Dec 1, 1992·Current Opinion in Genetics & Development·J A Armour, A J Jeffreys
Jan 1, 1992·Current Genetics·D C ChenT T Kuo
Oct 1, 1991·Molecular & General Genetics : MGG·J W WelchS Fogel
Mar 1, 1991·Molecular and Cellular Biology·B A Ozenberger, G S Roeder
Jul 1, 1990·Molecular & General Genetics : MGG·J W WelchS Fogel
Aug 1, 1988·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P J Hastings
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T L Orr-WeaverR J Rothstein
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T L Orr-Weaver, J W Szostak
Jan 1, 1983·Methods in Enzymology·R J Rothstein
May 1, 1983·Cell·J W SzostakF W Stahl
Jan 1, 1982·Annual Review of Genetics·K A Nasmyth
May 1, 1995·Genes & Development·G Gonzy-TréboulJ Deutsch
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·X ChenG Gupta
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y Nevo-Caspi, M Kupiec
May 1, 1994·Genetics·R Silberman, M Kupiec
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·D Thompson-StewartA C Spradling
Feb 1, 1994·Nature Genetics·A J JeffreysJ A Armour
Nov 19, 1993·Cell·L L Sandell, V A Zakian

❮ Previous
Next ❯

Citations

Jun 30, 2010·The Journal of Cell Biology·Masaoki KohzakiShunichi Takeda
May 25, 2010·FEBS Letters·Carrie A Adelman, Simon J Boulton
Jul 14, 2014·Nucleic Acids Research·Ivelina VassilevaBoyka Anachkova
Jan 6, 2009·Molecular Carcinogenesis·Guliang Wang, Karen M Vasquez
Dec 14, 2004·DNA Repair·Nadine PugetRalph Scully
Mar 27, 2016·Trends in Biotechnology·Chul-Yong ParkDong-Wook Kim
Jan 27, 2005·Cancer Letters·Christine Richardson
Jul 29, 2004·DNA Repair·Christine RichardsonTej K Pandita
May 22, 2004·American Journal of Human Genetics·Richard J L F LemmersSilvère M van der Maarel
Aug 10, 2013·FEMS Microbiology Reviews·Kai ZhouChris W Michiels
Jan 5, 2000·Molecular Cell·X Yu, A Gabriel
Oct 15, 2013·Molecular Cell·Gerard Mazón, Lorraine S Symington
Nov 9, 2007·PLoS Biology·Melissa S McMahillDouglas K Bishop
Sep 3, 2010·Annual Review of Genetics·Rita GemayelKevin J Verstrepen
Feb 3, 1999·Annual Review of Genetics·J E Haber
Jul 27, 2002·Annual Review of Genomics and Human Genetics·Ken Inoue, James R Lupski
Nov 14, 2012·Annual Review of Genetics·Anna Malkova, James E Haber
Apr 3, 2010·Nucleic Acids Research·Thomas RollandGuy-Franck Richard
Apr 10, 1999·Human Molecular Genetics·K TamakiA J Jeffreys
Jun 23, 2009·Human Molecular Genetics·Michael W KillenAndrew J Pierce
Mar 29, 2014·Genome Biology and Evolution·Elena BarghiniAndrea Cavallini
Nov 29, 2016·Nucleus·Francesco RomeoVincenzo Costanzo
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·E KrausJ E Haber
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·Z H ZhouM Jasin
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·D O FergusonF W Alt
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·C T McMurray
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·C JankowskiD K Nag
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·A MalkovaJ E Haber
Jul 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·E SonodaS Takeda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.