Expedient synthesis of C3-symmetric hexasubstituted benzenes via Nicholas reaction/[2 + 2 + 2] cycloaddition. new platforms for molecular recognition

Organic Letters
Romen CarrilloFernando Pinacho Crisóstomo

Abstract

An expedient methodology to synthesize macrocyclic compounds in one step based on the Nicholas reaction is disclosed. The key step features two intermolecular reactions followed by an intramolecular reaction from the starting dicobalt hexacarbonyl-propargylic complex. The macrocycles obtained were modified through [2 + 2 + 2] cycloaddition, generating two new C3-symmetric hexasubstituted benzene structures suitable for molecular recognition purposes.

References

Feb 14, 2004·Organic Letters·Fernando R P CrisóstomoVíctor S Martín
Feb 24, 2006·Chemical Communications : Chem Comm·Elsa AlvaroMiguel A Sierra
Mar 11, 2006·The Journal of Organic Chemistry·Fernando R Pinacho CrisóstomoVíctor S Martín
Jul 21, 2006·Organic & Biomolecular Chemistry·Bilge BaytekinChristoph A Schalley
May 10, 2007·Angewandte Chemie·Alessandro ScarsoFabrizio Fabris
May 23, 2008·Organic Letters·J Nicolás HernándezVíctor S Martín
Feb 19, 2009·Organic Letters·Nobuhiro Kihara, Kazuyuki Kidoba
Jun 26, 2009·Journal of the American Chemical Society·Barry M TrostRobert C Livingston
Oct 1, 2010·Chemical Society Reviews·Agnieszka Szumna
Apr 12, 2011·Accounts of Chemical Research·Fabrizio FabrisOttorino De Lucchi
Feb 26, 2013·Angewandte Chemie·Julio Rodríguez-LópezTomás Martín
Jun 12, 2013·Chemical Society Reviews·Yinghua JinWei Zhang

❮ Previous
Next ❯

Citations

Dec 15, 2017·Chemical Communications : Chem Comm·Jorge Borges-González, Tomás Martín
Jun 3, 2015·Organic Letters·Romen CarrilloFernando Pinacho Crisóstomo
Feb 7, 2018·The Journal of Organic Chemistry·Anna G LyapunovaIrina A Balova
Jul 19, 2017·The Journal of Organic Chemistry·Sedef KarabiyikogluCraig A Merlic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.