Expedited Biliopancreatic Juice Flow to the Distal Gut Benefits the Diabetes Control After Duodenal-Jejunal Bypass

Obesity Surgery
Haifeng HanSan-yuan Hu

Abstract

Serum bile acids (BAs) are elevated after metabolic surgeries including Roux-en-Y gastric bypass (RYGB), ileal transposition (IT), and duodenal-jejunal bypass (DJB). Recently, BAs have emerged as a kind of signaling molecules, which can not only promote glucagon-like peptide-1 (GLP-1) secretion but can also regulate multiple enzymes involved in glucose metabolism. The aim of this study was to investigate whether expedited biliopancreatic juice flow to the distal gut contributes to the increased serum GLP-1 and BAs and benefits the diabetes control after DJB. DJB, long alimentary limb DJB (LDJB), duodenal-jejunal anastomosis (DJA), and sham operation were performed in diabetic rats induced by high-fat diet (HFD) and low dose of streptozotocin (STZ). Body weight, food intake, oral glucose tolerance, insulin tolerance, glucose-stimulated insulin and GLP-1 secretion, fasting serum total bile acids (TBAs), and lipid profiles were measured at indicated time points. Compared with sham operation, DJA, DJB, and LDJB all achieved rapid and dramatic improvements in glucose tolerance and insulin sensitivity independently of food restriction and weight loss. DJB and LDJB-operated rats exhibited even better glucose tolerance, higher fasting ...Continue Reading

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Citations

Sep 15, 2015·International Journal of Endocrinology·XingChun WangShen Qu
Sep 20, 2018·Laboratory Animals·Elina AkalestouFrancesco Rubino
Aug 23, 2016·World Journal of Gastroenterology : WJG·Ming-Wei ZhongSan-Yuan Hu
Sep 27, 2018·Frontiers in Endocrinology·Blandine Laferrère, François Pattou
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Nov 5, 2021·Scientific Reports·Siqi XieShanGeng Weng

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