Experience and Outcomes at a Specialized Clostridium difficile Clinical Practice

Mayo Clinic Proceedings. Innovations, Quality & Outcomes
Raseen TariqSahil Khanna

Abstract

To report our experience with and outcomes among patients referred to a specialized Clostridium difficile clinical practice. We retrospectively identified consecutive patients referred for Clostridium difficile infection (CDI) management from January 1, 2013, through May 30, 2015. Data were collected for demographic characteristics, CDI history, final diagnoses, and management. Overall, 211 patients (median age, 65 years; 66.4% women) were included. The most common indications for referral were recurrent CDI in 199 patients (94.3%), first CDI episode in 5 patients (2.4%), and chronic diarrhea in 7 patients (3.3%). After evaluation, the diagnoses were recurrent CDI in 127 patients (60.2%), resolved CDI in 36 patients (17.1%), first-episode CDI in 5 patients (2.4%), and non-CDI in 43 patients (20.4%). The most common non-CDI diagnoses were postinfection irritable bowel syndrome (PI-IBS) in 32 patients (15.2% overall), inflammatory bowel disease (n=3), small intestinal bacterial overgrowth (n=2), microscopic colitis (n=1), and asymptomatic C difficile colonization (n=2). Two patients had diabetic gastroparesis and food intolerances, and 1 had chronic constipation with overflow diarrhea. Of 127 patients with recurrent CDI, 30 (23.6...Continue Reading

References

Mar 1, 1991·Diseases of the Colon and Rectum·P KofskyD Ufberg
Feb 2, 1999·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·L V McFarlandR N Greenberg
Nov 4, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bradley A Connor
Jun 8, 2006·Digestive Diseases and Sciences·Mark R BorgaonkarStephen M Collins
Nov 21, 2007·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·T PicheS M Collins
Oct 31, 2008·The New England Journal of Medicine·Ciarán P Kelly, J Thomas LaMont
Apr 5, 2011·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Becky A MillerDeverick J Anderson
Aug 30, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Johan S BakkenUNKNOWN Fecal Microbiota Transplantation Workgroup
Nov 24, 2011·The American Journal of Gastroenterology·Sahil KhannaAlan R Zinsmeister
May 2, 2012·Nature Reviews. Gastroenterology & Hepatology·Sahil Khanna, Darrell S Pardi
Jan 18, 2013·The New England Journal of Medicine·Els van NoodJosbert J Keller
Feb 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sahil KhannaDarrell S Pardi
Feb 27, 2013·The American Journal of Gastroenterology·Christina M SurawiczBrian S Zuckerbraun
Mar 21, 2013·The American Journal of Gastroenterology·Zain KassamRichard H Hunt
Mar 4, 2014·Therapeutic Advances in Gastroenterology·Sahil Khanna, Darrell S Pardi
Mar 29, 2014·The New England Journal of Medicine·Shelley S MagillUNKNOWN Emerging Infections Program Healthcare-Associated Infections and Antimicrobial Use Prevalence Survey Team
Apr 3, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gauree G KonijetiAshwin N Ananthakrishnan
Apr 20, 2014·World Journal of Gastroenterology : WJG·Jennifer K BeattyAndre G Buret
May 7, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Hoonmo L KooHerbert L DuPont
Jan 28, 2015·JAMA : the Journal of the American Medical Association·Natasha BagdasarianPreeti N Malani
Feb 26, 2015·The New England Journal of Medicine·Fernanda C LessaL Clifford McDonald
Mar 4, 2015·The American Journal of Gastroenterology·Ioannis M ZacharioudakisEleftherios Mylonakis
May 6, 2015·Annals of Internal Medicine·Dimitri DrekonjaTimothy J Wilt
Nov 14, 2015·Journal of Clinical Gastroenterology·Melissa JacksonColleen R Kelly
Jul 23, 2016·Alimentary Pharmacology & Therapeutics·A WadhwaM Grover
Dec 14, 2016·JAMA : the Journal of the American Medical Association·Arjun Gupta, Sahil Khanna

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Citations

May 21, 2019·Therapeutic Advances in Gastroenterology·Srishti Saha, Sahil Khanna
Jan 20, 2020·The FEBS Journal·Placido IllianoCinzia Parolini
Sep 26, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Srishti SahaSahil Khanna
Apr 1, 2021·Therapeutic Advances in Gastroenterology·Elida VothSahil Khanna
Feb 28, 2021·Gastroenterology·Colleen R KellyLoren A Laine
May 19, 2021·The American Journal of Gastroenterology·Colleen R KellyNeil H Stollman
Sep 23, 2020·ACS Infectious Diseases·David M LyerlyGlenn S Tillotson

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Methods Mentioned

BETA
PCR

Software Mentioned

JMP

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