Experience and Prognosis of Systemic Neonatal Thrombosis at a Level III NICU

Journal of Pediatric Hematology/oncology
Sevim UnalNeşe Yarali

Abstract

The objective of this article was to evaluate neonates diagnosed systemic thrombosis and their outcomes. We retrospectively evaluated data of neonatal systemic thrombosis between January 2011 and December 2016. Among 4376 hospitalized, 30 neonates (0.69%) were diagnosed systemic thrombosis. Their mean birth weight was 2422±1152 g (680 to 4750 g), gestational age was 35±5.4 weeks (25 to 41 wk). There were 25 neonates (83.3%) with venous, 5 patients (16.7%) with arterial thrombosis. The most common sites that thrombi localized were major vessels (n=11) and central nervous system (n=8). Central catheter insertion (76.7%) and prematurity (46.7%) were the most common risk factors. Congenital prothrombotic risk factors included G1691A mutation in factor V Leiden (n=1), mutation in factor XIII (n=1), C677T mutation in methylenetetrahydrofolate reductase (n=6). More than 1 congenital risk factor was identified in 5 patients. The patients were treated with low-molecular weight heparin. The mortality rate was 13.3% (n=4). Two patients required amputation (left foot, left upper extremity). Unilateral renal atrophy (n=1), cerebral palsy (n=2), hemiparesis (n=1) were identified among followed 24 patients. Critically ill neonates are at risk...Continue Reading

References

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Citations

Aug 2, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mustafa KaraNaci Ceviz
Jul 28, 2020·Pediatric Blood & Cancer·Priscila Grizante-LopesJorge David Aivazoglou Carneiro
Jun 9, 2021·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·James TingUNKNOWN Thrombosis and Hemostasis in Newborns (THiN) Group
Nov 21, 2021·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Işik Odaman AlTuba Hilkay Karapinar

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Methods Mentioned

BETA
amputation

Software Mentioned

SPSS

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