Experience-dependent trends in CA1 theta and slow gamma rhythms in freely behaving mice

Journal of Neurophysiology
Brian J GerekeLaura Lee Colgin

Abstract

CA1 place cells become more anticipatory with experience, an effect thought to be caused by NMDA receptor-dependent plasticity in the CA3-CA1 network. Theta (~5-12 Hz), slow gamma (~25-50 Hz), and fast gamma (~50-100 Hz) rhythms are thought to route spatial information in the hippocampal formation and to coordinate place cell ensembles. Yet, it is unknown whether these rhythms exhibit experience-dependent changes concurrent with those observed in place cells. Slow gamma rhythms are thought to indicate inputs from CA3 to CA1, and such inputs are thought to be strengthened with experience. Thus, we hypothesized that slow gamma rhythms would become more evident with experience. We tested this hypothesis using mice freely traversing a familiar circular track for three 10-min sessions per day. We found that slow gamma amplitude was reduced in the early minutes of the first session of each day, even though both theta and fast gamma amplitudes were elevated during this same period. However, in the first minutes of the second and third sessions of each day, all three rhythms were elevated. Interestingly, theta was elevated to a greater degree in the first minutes of the first session than in the first minutes of later sessions. Additio...Continue Reading

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Citations

Oct 15, 2019·ELife·Zoé Christenson WickEsther Krook-Magnuson
Mar 6, 2021·Frontiers in Systems Neuroscience·Arthur S C FrançaMichael X Cohen
Jun 9, 2021·Nature Communications·Chenguang ZhengLaura Lee Colgin

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