Experience of social discrimination correlates with neurometabolism: a pilot study in heroin addicts.

European Archives of Psychiatry and Clinical Neuroscience
Ulrich FrischknechtGabriele Ende

Abstract

Experimental social neuroscience has shown that being socially excluded is processed in the anterior cingulate cortex (ACC). We hypothesize that a chronic form of social exclusion resembling one aspect of social stigmatization is associated with altered neural plasticity reflected by neurometabolic alterations in the ACC. To test this hypothesis, a highly stigmatized patient group of heroin addicts (N = 15) during opiate maintenance therapy rated a questionnaire about being stigmatized, and neurometabolic markers in the ACC were determined using (1)H MR spectroscopy. We found a negative correlation between discrimination experience and N-acetylaspartate (NAA), indicating attenuated neuron functioning in the anterior cingulate cortex in those patients reporting high discrimination experience. Furthermore, perceived stigmatization showed an association with anxiety that was mediated by NAA. Although the correlative analysis cannot give evidence for a causal relationship, the relation of NAA in the ACC and discrimination experience indicates a malfunction of the neural system involved in cognitive control over emotionally relevant social stimuli in discrimination reporting heroin addicts. Further research is needed to elucidate fa...Continue Reading

References

Mar 1, 1969·Biochemical Pharmacology·F Marcucci, E Giacalone
Nov 1, 1982·Journal of Studies on Alcohol·H A Skinner, W J Sheu
May 29, 2000·Trends in Cognitive Sciences·G BushM I Posner
Apr 24, 2001·Psychological Bulletin·R Kurzban, M R Leary
Jul 5, 2001·Physiology & Behavior·R J BlanchardD C Blanchard
Jul 9, 2002·Psychiatrische Praxis·Adrian FreiUNKNOWN Arbeitsgruppe HeGeBe Doppeldiagnosen
Jul 9, 2002·Psychiatrische Praxis·Adrian Frei, Jürgen Rehm
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Oct 11, 2003·Science·Naomi I EisenbergerKipling D Williams
Oct 24, 2003·Psychiatry Research·Jennifer Boyd RitsherMonica Grajales
Oct 21, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ali Saffet GonulSimavi Vahip
Jan 18, 2006·Biological Psychiatry·Sheila C CaetanoJair C Soares
Feb 14, 2006·Lancet·Gerald T KeuschArthur Kleinman
Jul 5, 2006·Nature Neuroscience·Leah H SomervilleWilliam M Kelley
Aug 25, 2007·Annual Review of Clinical Psychology·Stephen P Hinshaw, Andrea Stier
May 28, 2008·Epilepsia·Jullie W PanDennis D Spencer
Mar 12, 2008·European Archives of Psychiatry and Clinical Neuroscience·Golo KronenbergMichael Colla
Dec 23, 2008·The Journal of Pain : Official Journal of the American Pain Society·Justin L HayBruce Rounsefell
Feb 19, 2009·European Archives of Psychiatry and Clinical Neuroscience·Georg SchomerusMatthias C Angermeyer
May 28, 2009·Social Cognitive and Affective Neuroscience·Carrie L MastenMirella Dapretto
Jul 10, 2009·Psychological Bulletin·Elizabeth A Pascoe, Laura Smart Richman
Sep 1, 2009·Trends in Cognitive Sciences·Rita Z GoldsteinNora D Volkow
Oct 20, 2009·European Archives of Psychiatry and Clinical Neuroscience·Frank HölscherNorbert Scherbaum
Mar 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Dirk WedekindUrsula Havemann-Reinecke
Mar 17, 2010·European Archives of Psychiatry and Clinical Neuroscience·Nicolas RüschPatrick W Corrigan
Jun 17, 2010·Psychological Medicine·C SehlmeyerC Konrad
Sep 8, 2010·European Archives of Psychiatry and Clinical Neuroscience·Anne SchienleAxel Schäfer
Oct 12, 2010·Drug and Alcohol Dependence·Georg SchomerusMichael Lucht
Oct 12, 2010·European Archives of Psychiatry and Clinical Neuroscience·Krystyna A MathiakKlaus Mathiak
Oct 19, 2010·European Archives of Psychiatry and Clinical Neuroscience·Karl Mann, Derik Hermann
Dec 17, 2010·Current Topics in Behavioral Neurosciences·Thomas Lundqvist
Dec 24, 2010·European Addiction Research·Pier Paolo PaniLiliana Dell'osso
Apr 14, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael SoykaUNKNOWN WFSBP Task Force on Treatment, Guidelines for Substance Use Disorders
Apr 19, 2011·European Archives of Psychiatry and Clinical Neuroscience·Martina de ZwaanAlexandra Philipsen
Jun 24, 2011·Nature·Florian LederbogenAndreas Meyer-Lindenberg
Aug 25, 2011·European Archives of Psychiatry and Clinical Neuroscience·Birgit Derntl, Ute Habel
Sep 29, 2011·European Archives of Psychiatry and Clinical Neuroscience·Wolfgang GaebelNorman Sartorius

❮ Previous
Next ❯

Citations

Mar 5, 2013·European Archives of Psychiatry and Clinical Neuroscience·Andrea Schmitt, Peter Falkai
Mar 29, 2014·Current Behavioral Neuroscience Reports·Mark J Niciu, Graeme F Mason
May 22, 2013·European Archives of Psychiatry and Clinical Neuroscience·Nicolas RüschWulf Rössler
Jan 24, 2016·European Archives of Psychiatry and Clinical Neuroscience·Rilana SchusterAnnemarie Heberlein
Nov 20, 2014·Stress : the International Journal on the Biology of Stress·Maximus Berger, Zoltán Sarnyai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.