Experience with a placebo-controlled randomized clinical trial of a disease-modifying drug for osteoarthritis: the doxycycline trial

Rheumatic Diseases Clinics of North America
Kenneth D Brandt, Steven A Mazzuca

Abstract

Little effort has gone into the development of more effective analgesics for osteoarthritic pain. Efforts to improve symptomatic therapy for osteoarthritis have been deflected or diluted by a decision to pursue the development of disease-modifying OA drugs (DMOADs). These agents' main mechanism of action is directed not at the relief of joint pain but at slowing the progression of structural damage. This article describes the results of a recent randomized placebo-controlled designed to examine the DMOAD effect in humans of the tetracycline antibiotic doxycycline, and reviews the experience gained from other recent DMOAD trials in humans.

References

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Citations

Apr 14, 2010·Cell and Tissue Banking·Silvia Díaz-PradoFrancisco J Blanco
Jan 24, 2013·Therapeutic Advances in Chronic Disease·Lia PulsatelliRiccardo Meliconi
Feb 23, 2011·Differentiation; Research in Biological Diversity·Silvia Díaz-PradoFrancisco J Blanco
Oct 9, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Lisa A FortierKaren G Mayr
May 22, 2010·Equine Veterinary Journal·L V SchnabelL A Fortier
Mar 15, 2011·Osteoarthritis and Cartilage·J M JordanM Wahba
Nov 17, 2010·The Journal of Rheumatology·Tamara Hermida-GómezFrancisco Javier Blanco
Apr 17, 2009·The Journal of Rheumatology·Ananthila AnandacoomarasamyLyn M March
Dec 20, 2008·Current Opinion in Rheumatology·Ananthila AnandacoomarasamyLyn March
Nov 16, 2012·The Cochrane Database of Systematic Reviews·Bruno R da CostaAnne W S Rutjes

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