Abstract
The emergence of beta-lactamase-mediated resistance to established beta-lactam antibiotics prompted the development of beta-lactamase inhibitors for co-administration. Ampicillin has been combined with sulbactam for both parenteral and oral (as the mutual pro-drug sultamicillin) administration. The combination is active in vitro against a wide variety of Gram-positive and Gram-negative pathogens, including aerobic and anaerobic organisms. In clinical trials, ampicillin/sulbactam has proved clinically and bacteriologically effective against a variety of frequently encountered pediatric infections, including mild-to-moderate upper respiratory tract infections (acute otitis media, sinusitis, pharyngitis, and tonsillitis), severe post-operative and intra-abdominal infections, periorbital infections (which, left untreated, can lead to blindness, brain abscess, or death), acute epiglottitis, bacterial meningitis, and brain abscess. Ampicillin/sulbactam has also proved effective in the prevention of post-operative surgical infections in pediatric patients. The clinical efficacy profile of ampicillin/sulbactam and sultamicillin, combined with their excellent tolerability profile, make these agents attractive options for the management ...Continue Reading
References
Jan 1, 1979·Archives of Disease in Childhood·L S Lewis
Jul 1, 1989·Diagnostic Microbiology and Infectious Disease·G KanraO Tarim
Apr 1, 1989·Drugs·H A FriedelK L Goa
Jan 1, 1989·Journal of Clinical Apheresis·P AhmedH Chaplin
Nov 1, 1986·Reviews of Infectious Diseases·J H KimI S Yang
Nov 1, 1986·Reviews of Infectious Diseases·P Hänninen, T Rossi
Nov 1, 1986·Reviews of Infectious Diseases·J P StahlM Micoud
Nov 1, 1986·Reviews of Infectious Diseases·E WaldD Chiponis
Nov 1, 1986·Reviews of Infectious Diseases·W J RodríguezS Ahmad
Nov 1, 1986·Reviews of Infectious Diseases·M C FosterR C Slack
Mar 1, 1966·The Journal of Pediatrics·E R Stiehm, D S Damrosch
Jun 1, 1995·The Pediatric Infectious Disease Journal·G Y KanraE Belgin
Jun 1, 1994·Diagnostic Microbiology and Infectious Disease·P R MurrayR B Lankford
Jun 1, 1993·Journal of Chemotherapy·M AkovaA Erbengi
Jan 1, 1993·The Pediatric Infectious Disease Journal·K H ChanP A Fall
Aug 1, 1996·International Journal of Radiation Oncology, Biology, Physics·T E MerchantS A Leibel
Aug 1, 1996·Acta Paediatrica Japonica; Overseas Edition·G KanraZ Ecevit
Aug 1, 1996·Journal of Chemotherapy·M AkovaH E Akalin
Sep 25, 1997·JAMA : the Journal of the American Medical Association·P B McIntyreC M Perez
Mar 31, 1998·The Pediatric Infectious Disease Journal·C M Alpuche-Aranda
Mar 31, 1998·The Pediatric Infectious Disease Journal·E L López, N A Rivas
Mar 31, 1998·The Pediatric Infectious Disease Journal·M D CollinsR Swanson
Sep 24, 1999·The Pediatric Infectious Disease Journal·K G DawsonJ L Burns
Apr 12, 2000·The Journal of Antimicrobial Chemotherapy·D AdamM Helmerking
Citations
Jul 23, 2009·Expert Opinion on Drug Metabolism & Toxicology·Alex P Betrosian, Emmanuel E Douzinas
Jun 10, 2008·International Journal of Antimicrobial Agents·Hartmut M Lode
Dec 25, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M Akova
Dec 8, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Kyung-Eon LeeSeong Yun Kim