Abstract
A prospective, open-label, randomized, comparative study in pediatric cancer patients was conducted to evaluate the efficacy and safety of cefepime and meropenem in the empiric therapy of febrile neutropenic patients. Febrile episodes were classified as microbiologically documented infection, clinical documented infection, or fever of unknown origin. Clinical response to therapy was classified as success or failure. In this period 37 children with solid tumors including lymphoma, 25 males, 12 females, had neutropenia on 65 occasions. Microbiologically documented infections occurred in 21 episodes (32.31%). Frequency of positive bacteria isolated was higher than gram-negative bacteria. There was no infection-related death. There were no statistical differences between the cefepime and meropenem groups for duration of fever or neutropenia, response rate, and necessity for modification. Cefepime appears to be as effective and safe as meropenem for empiric treatment of febrile episodes in neutropenic pediatric cancer patients.
References
Jan 1, 1989·Chemotherapy·G BucaneveA Del Favero
Mar 1, 1989·Infection·J Klastersky
Nov 1, 1989·Reviews of Infectious Diseases·G P Bodey
Aug 28, 1986·The New England Journal of Medicine·P A PizzoJ McKnight
Mar 1, 1984·The American Journal of Medicine·P A PizzoK J Robichaud
Jul 1, 1995·Drugs·L R WisemanH M Bryson
Nov 1, 1993·The Journal of Antimicrobial Chemotherapy·P EggimannT Calandra
Nov 1, 1993·The Journal of Antimicrobial Chemotherapy·C ThornsberryT Rich
Mar 1, 1993·Chemotherapy·F LeoniP Rossi Ferrini
Jul 1, 1995·The Journal of Antimicrobial Chemotherapy·J R Edwards
Jun 24, 1996·The American Journal of Medicine·R RamphalD Oblon
Aug 1, 1997·Antimicrobial Agents and Chemotherapy·D YamamuraC Rotstein
Oct 6, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W T HughesL S Young
Dec 24, 1997·British Journal of Haematology·I HannM Glauser
Oct 28, 1998·Scandinavian Journal of Infectious Diseases·R LindbladI Turesson
Sep 4, 1999·Chemotherapy·F D WangC H Ho
Mar 31, 2000·Medical and Pediatric Oncology·P ChastagnerD Sommelet
Mar 22, 2001·Medical and Pediatric Oncology·R KebudiK Töreci
Apr 17, 2001·The Pediatric Infectious Disease Journal·M M MustafaG R Buchanan
Apr 18, 2001·Chemotherapy·B M JándulaJ Sierra
Sep 19, 2001·Chemotherapy·J R BorbollaR M Jiménez
Feb 19, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Walter T HughesLowell S Young
Aug 28, 2003·Cancer·Issam I RaadKenneth V I Rolston
Jan 31, 2004·Pediatric Blood & Cancer·Tezer KutlukGülten Seçmeer
Citations
Jan 6, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alison G Freifeld Infectious Diseases Society of Americaa
Jan 25, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alison G Freifeld Infectious Diseases Society of America
Feb 13, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Masaki FujitaUNKNOWN Lung Oncology Group in Kyushu (LOGIK)
Sep 18, 2010·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·X Durrmeyer, R Cohen
Sep 12, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Sema VuralRejin Kebudi
Jan 11, 2013·Pediatric Hematology and Oncology·Metin DemirkayaMustafa Hacımustafaoglu
May 4, 2010·The Journal of Pediatrics·Elisabeth E AddersonJames M Hoffman
Mar 30, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paula D RobinsonLillian Sung
Dec 17, 2011·The Pediatric Infectious Disease Journal·Arif ManjiLillian Sung
Nov 12, 2010·The Cochrane Database of Systematic Reviews·Mical PaulLeonard Leibovici
Apr 7, 2009·Journal of Pediatric Hematology/oncology·Ryoji KobayashiAkihiro Iguchi
Dec 6, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Arif ManjiLillian Sung
Aug 2, 2017·Open Forum Infectious Diseases·Nikolaos AndreatosEleftherios Mylonakis
Mar 22, 2018·Frontiers in Pediatrics·Saber JanMaria Gutierrez
Mar 3, 2019·Annals of Hematology·Tatsuo OyakeYoji Ishida
Mar 19, 2011·Pediatric Hematology and Oncology·Hacı Ahmet DemirMünevver Büyükpamukçu
Mar 6, 2021·Medicine·Ying WangZhitang Yang