PMID: 8945709Nov 1, 1996Paper

Experience with infection by Scedosporium prolificans including apparent cure with fluconazole therapy

The Journal of Infection
R W PicklesW H Merrell

Abstract

Five cases of human infection with Scedosporium prolificans are described. There were two groups of patients. In group one, two were immunocompetent males with localized bone and joint infections, a man with post-traumatic septic arthritis, responded to surgical treatment alone and a boy with post-traumatic septic arthritis, appeared to respond to treatment with oral fluconazole, without surgery. The second group consisted of three immunocompromised patients. S. prolificans was isolated at autopsy from the lungs of one patient with acute leukaemia, and from the lungs, liver, and kidneys of another. Nosocomial S. prolificans infection of a synthetic vascular graft occurred in the third patient with end-stage renal failure on corticosteroid therapy for idiopathic hypereosinophilia. His infection failed to respond to combinations of surgery, fluconazole and itraconazole. All isolates of S. prolificans were resistant in vitro to antifungal drugs, including the first case, which responded clinically to fluconazole.

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Aug 1, 1990·Southern Medical Journal·E C ToyE R Leibovitch
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Citations

Nov 26, 2008·Medical Mycology·Juan Luis Rodriguez-TudelaManuel Cuenca-Estrella
May 8, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P IdigorasJ M González
Jan 18, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sanjay G RevankarMichael G Rinaldi
Dec 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shahid HusainNina Singh
Jan 4, 2008·Surgical Infections·Carolien M KooijmanMichel M P J Reijnen
Dec 26, 2001·Antimicrobial Agents and Chemotherapy·Joseph MeletiadisUNKNOWN EUROFUNG Network
Oct 12, 2010·Clinical Microbiology Reviews·Sanjay G Revankar, Deanna A Sutton
Jan 19, 2008·Clinical Microbiology Reviews·Karoll J CortezThomas J Walsh
Aug 15, 2001·Pharmacotherapy·R E Lewis, D P Kontoyiannis
Jun 8, 2001·Journal of the American Veterinary Medical Association·T W SwerczekR J Hunt
Oct 10, 2009·Journal of the American Academy of Dermatology·Marília Marufuji OgawaJosé Osmar Medina-Pestana
Jul 4, 2006·ANZ Journal of Surgery·Philip A DaltonDavid W Walters
Oct 17, 2008·Mycoses·Manfred KnokeGünther Schwesinger
Jan 8, 2004·Journal of Chemotherapy·W J Steinbach, J R Perfect
Dec 12, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E SimarroJ Ruiz
Feb 20, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A M TortoranoC Lass-Flörl
Dec 20, 2015·Medicine·Saad J Taj-AldeenUNKNOWN International Osteoarticular Mycoses Consortium

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