Experience with the systemic treatment of severe forms of psoriasis

Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Martin Tichý, Jana Zapletalova

Abstract

Severe forms of psoriasis are indicated for systemic treatment with conventional and biological preparations. The former includes methotrexate, cyclosporin, acitretin and narrow-band ultraviolet B phototherapy but toxicity may limit the dose and duration of treatment. Currently used less toxic biological preparations include inhibitors of TNF-alpha (etanercept, adalimumab, infliximab) and the monoclonal antibody against IL 12/23 ustekinumab. We present our own more than five-year experience with the systemic treatment of severe forms of psoriasis using these preparations. A total of 66 patients treated with systemic therapy (except for phototherapy) were divided into groups based on treatment. Therapeutic doses were administered according to the recommendations of the manufacturer and dermatological societies. Standard PASI and BSA indexes were used to evaluate clinical condition at weeks 0, 12 and 24. Differences in PASI score reduction and BSA index between patient groups treated with different preparations were statistically significant at monitored intervals. At week 12, PASI score was reduced by 75% or more in a significantly greater number of patients treated with infliximab + methotrexate than those treated with acitreti...Continue Reading

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Aug 7, 2013·Dermatologic Therapy·Olubukola Babalola, Bruce E Strober
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Nov 25, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·M TichyJ Sternbersky

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