Experience With the Use of Rituximab for the Treatment of Rheumatoid Arthritis in a Tertiary Hospital in Spain: RITAR Study

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
Iciar CañamaresIsidoro González-Álvaro

Abstract

There is evidence supporting that there are no relevant clinical differences between dosing rituximab 1000 mg or 2000 mg per cycle in rheumatoid arthritis (RA) patients in clinical trials, and low-dose cycles seem to have a better safety profile. Our objective was to describe the pattern of use of rituximab in real-life practice conditions. Rituximab for RA in clinical practice (RITAR) study is a retrospective cohort study from 2005 to 2015. Eligibility criteria were RA adults treated with rituximab for active articular disease. Response duration was the main outcome defined as months elapsed from the date of rituximab first infusion to the date of flare. A multivariable analysis was performed to determine the variables associated with response duration. A total of 114 patients and 409 cycles were described, 93.0% seropositive and 80.7% women. Rituximab was mainly used as second-line biological therapy. On demand retreatment was used in 94.6% of cases versus fixed 6 months retreatment in 5.4%. Median response duration to on demand rituximab cycles was 10 months (interquartile range, 7-13). Multivariable analysis showed that age older than 65 years, number of rituximab cycles, seropositivity, and first- or second-line therapy we...Continue Reading

References

Jun 18, 2004·The New England Journal of Medicine·Jonathan C W EdwardsTim Shaw
May 28, 2010·Arthritis and Rheumatism·J-E GottenbergUNKNOWN AutoImmunity and Rituximab registry and French Society of Rheumatology
Jul 29, 2011·Reumatología clinica·Emilio Martín MolaUNKNOWN el grupo de Expertos en Rituximab
Aug 29, 2014·Current Pharmaceutical Design·Geraldine Cambridge, Inmaculada De La Torre
Dec 30, 2014·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Heikki VallealaPekka Hannonen
Feb 18, 2016·Arthritis Research & Therapy·Katerina ChatzidionysiouUNKNOWN Rheumatic Diseases Portuguese Register
Jun 9, 2016·Rheumatology International·Emilio Martin-MolaEstíbaliz Loza
Feb 1, 2017·Lancet·Raphaèle Seror, Xavier Mariette

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Citations

Mar 7, 2020·Arthritis & Rheumatology·Md Yuzaiful Md YusofSinisa Savic

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