PMID: 2486349Jan 1, 1989Paper

Experiences from the use of Fibrinkleber in oral and maxillofacial surgery

Hellenika stomatologika chronika. Hellenic stomatological annals
N Lasaridis, A Merten

Abstract

The combination of highly concentrated fibronogen, thrombin, clotting factor XIII and fibrinolytic inhibitor aprotinin, represents a new biological, haemostatic and adhesive system as "Fibrinkleber". Its way of action is the same as phase II of coagulation mechanism and its result is due to the formation of a strong and extensive fibrin clot. Because of the presence of aprotinin, that inhibits fibrinolysis, this clot remains for a longer period. A fast haemostasis and a maintenance of tissues in contact is attained and the healing becomes easier and accelerated. In addition, Fibrinkleber is completely resorbable and has very good tissue compatibility, contrary to synthetic adhesives. Regarding experimental results the fibrin adhesive system has been applied in 58 clinical cases with the indications: 1. convocation of fistulas introoral or extraoral 2. as biological band 3. extraoral fixation of skin grafts, used in areas with poor possibility of other kinds of skin fixation 4. in cases with clef lip and cleft palace 5. in combination with bioceramic materials 6. in combination with lyo-dura for reconstruction of orbita-floor fractures. We believe that the fibrinkleber cannot help a bad surgical technique nor replace a well made...Continue Reading

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