Experiences of treating allergic rhinitis with intra-nasal beclomethasone dipropionate. Short-term trials and long-term follow-up

Acta Allergologica
E HolopainenE Tarkiainen

Abstract

The effect of locally acting intra-nasal beclomethasone dipropionate was observed in 42 patients suffering from seasonal allergic rhinitis and 50 patients suffering from perennial rhinitis. The study consists of three parts: 1) a simple double-blind trial in seasonal rhinitis, 2) a double-blind crossover trial in perennial rhinitis, 3) a 1-year follow-up of the perennial group. The active drug was significantly superior to placebo when comparing subjective symptoms, nasal resistance and secretion eosinophilia in the patients. In long-term use it was possible to reduce the initial dose considerably. On objective examination no significant changes were seen in the epithelium following long-term use. No suppression of the hypothalamic-pituitary-adrenal axis was observed after 1 year's regular use of beclomethasone dipropionate. The side effects were mild, the most common complaint being irritation of the nasal mucous membrane, apparently caused by the propellant gas.

References

Nov 1, 1975·Archives of Disease in Childhood·P PrahlN Mygind
Feb 1, 1975·Postgraduate Medical Journal·J E Hale
Sep 1, 1973·Archives of Disease in Childhood·S Godfrey, P König

Citations

Jan 1, 1977·British Journal of Clinical Pharmacology·D Poynter
Aug 1, 1979·Current Problems in Pediatrics·S C SiegelR M Katz
Dec 1, 1992·Clinical Otolaryngology and Allied Sciences·D E PhillipsJ Gilles
Oct 1, 1982·Clinical Otolaryngology and Allied Sciences·N Mygind
Jan 27, 2007·The Cochrane Database of Systematic Reviews·J J Al SayyadA Jamal

Related Concepts

Administration, Intranasal
Aerosol Dose Form
Bronchocort
Clinical Trials
Drug Evaluation
Hay Fever
Nasal Epithelium
Seasonal Variation

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