Experiences of treating allergic rhinitis with intra-nasal beclomethasone dipropionate. Short-term trials and long-term follow-up

Acta Allergologica
E HolopainenE Tarkiainen


The effect of locally acting intra-nasal beclomethasone dipropionate was observed in 42 patients suffering from seasonal allergic rhinitis and 50 patients suffering from perennial rhinitis. The study consists of three parts: 1) a simple double-blind trial in seasonal rhinitis, 2) a double-blind crossover trial in perennial rhinitis, 3) a 1-year follow-up of the perennial group. The active drug was significantly superior to placebo when comparing subjective symptoms, nasal resistance and secretion eosinophilia in the patients. In long-term use it was possible to reduce the initial dose considerably. On objective examination no significant changes were seen in the epithelium following long-term use. No suppression of the hypothalamic-pituitary-adrenal axis was observed after 1 year's regular use of beclomethasone dipropionate. The side effects were mild, the most common complaint being irritation of the nasal mucous membrane, apparently caused by the propellant gas.


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Jan 1, 1977·British Journal of Clinical Pharmacology·D Poynter
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Dec 1, 1992·Clinical Otolaryngology and Allied Sciences·D E PhillipsJ Gilles
Oct 1, 1982·Clinical Otolaryngology and Allied Sciences·N Mygind
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Related Concepts

Administration, Intranasal
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Clinical Trials
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