Experimental aerosol infection of cattle (Bos taurus) with ovine herpesvirus 2 using nasal secretions from infected sheep

Veterinary Microbiology
Naomi S TausHong Li

Abstract

Infection of clinically susceptible ruminants, including domesticated cattle and American bison, with ovine herpesvirus 2 (OvHV-2) can result in the fatal lymphoproliferative and vasculitis syndrome known as malignant catarrhal fever (MCF). A reliable experimental infection model is needed to study the pathogenesis of MCF and to develop effective vaccination strategies to control the disease. An experimental aerosol infection model using sheep, the natural carriers of OvHV-2, has been developed (Taus et al., 2005). Using the protocol and OvHV-2 inoculum established in the previous study, eight calves were nebulized with four different doses of OvHV-2 in nasal secretions from infected sheep. Two control calves were nebulized with nasal secretions from uninfected sheep. Infection status of all calves was monitored using competitive inhibition ELISA, PCR and clinical parameters. Six of eight nebulized calves became infected with OvHV-2. One calf receiving the highest dose of virus developed typical clinical, gross and histological changes of MCF. This study showed that nasal secretions collected from sheep experiencing OvHV-2 shedding episodes were infectious for cattle and capable of inducing MCF. The data also indicate that catt...Continue Reading

References

Mar 25, 1978·The Veterinary Record·I E SelmanM Murray
Jan 1, 1995·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·D O'TooleT Crawford
Jan 1, 1993·Archives of Virology·S I BaxterH W Reid
Jul 6, 1996·The Veterinary Record·P Collery, A Foley
Jun 29, 2001·Journal of Comparative Pathology·L J CoulterH W Reid
Sep 21, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·J BrennerD David
Dec 8, 2004·Journal of Clinical Microbiology·Hong LiTimothy B Crawford
Feb 5, 2005·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·John Andrew BerezowskiMurray Woodbury
Feb 22, 2005·The Journal of General Virology·Naomi S TausHong Li
Mar 29, 2006·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Hong LiTimothy B Crawford

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Citations

Nov 11, 2011·International Journal of Molecular Sciences·Hong LiNaomi S Taus
Jan 16, 2014·Indian Journal of Virology : an Official Organ of Indian Virological Society·Richa SoodS Bhatia
Sep 2, 2008·The Veterinary Journal·George C RussellDavid M Haig
Jun 10, 2008·Veterinary Microbiology·Katherine L GailbreathHong Li
Jun 5, 2007·Veterinary Microbiology·Björn JacobsenWolfgang Baumgärtner
Jun 19, 2008·The Journal of General Virology·Hong LiNaomi S Taus
Jan 1, 2013·Journal of Virological Methods·Hong LiNaomi S Taus
Nov 11, 2014·Annual Review of Animal Biosciences·Hong LiDonald P Knowles
Jul 5, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Donald L TraulHong Li
Jun 17, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Selwyn Arlington HeadleyCristina Wetzel Cunha
Dec 16, 2006·The Journal of General Virology·Jane HartJames P Stewart
Dec 8, 2020·Veterinary Pathology·Helena Saura-MartinezAnja Kipar
Jun 26, 2021·Journal of Veterinary Science·Aayesha RiazRuqia Baig

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