PMID: 7018159Jan 1, 1981Paper

Experimental allergic encephalomyelitis. Exsudate and cellular infiltrates in the spinal cord of Lewis rats

Acta Neuropathologica
H P AckermannP U Heitz

Abstract

Classical acute allergic encephalomyelitis (EAE) was provoked in Lewis rats with bovine spinal cord (BWM) in complete Freund's adjuvant (CFA). An efficient immunohistologic technique (peroxidase-antiperoxidase (PAP) was used to trace exsudates of fibrinogen and immunoglobulin as well as their coexistence with cellular infiltrates and clinical signs. Exsudation was restricted to the vessels exhibiting cellular infiltrates. The findings do not lend support to the assumption that exsudation of circulating factors is the initial local event in EAE. It also remains open, whether the exsudation of fibrinogen and gamma globulin are responsible for the clinical symptoms.

References

Jul 1, 1979·Hospital Practice·P Y Paterson, E D Day
Oct 1, 1967·Journal of Neuropathology and Experimental Neurology·R W CutlerC F Barlow
Jan 1, 1960·The Journal of Experimental Medicine·P Y PATERSON

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.