PMID: 6170738Oct 1, 1981Paper

Experimental allergic encephalomyelitis induced by basic protein with synthetic adjuvant in comparison with Freund's complete adjuvant. Role of antibodies in correlation with the clinicopathological features

Journal of the Neurological Sciences
E MitsuzawaS Ohtani

Abstract

Experimental allergic encephalomyelitis (EAE) was induced in guinea pigs with bovine myelin basic protein (BP) with adjuvant of either synthetic muramyl dipeptide (Mdp) or Mycobacterium tuberculosis (Tbc). The following results were obtained: (1) The body temperature of the animals was studied serially after sensitization and its elevation was shown to be an early sign of EAE. (2) Several animals developed the clinical and histological signs of hyperacute EAE. (3) An optimal combined dosage of BP and adjuvant was found for induction of clinical EAE and for the the production of complement fixing (CF) antibodies. (4) Little passive hemagglutinating (PH) antibody was produced by single immunization. These results displayed no essential difference in EAE induced by either adjuvant. (5) Detectable PH antibodies developed later in addition to CF antibodies in a few animals immunized with Tbc adjuvant. These animals were skin-tested to BP, and had recovered from body weight loss or limb weakness. The results suggest that humoral antibodies play a role in modifying the disease process, even if they are not essential in production of EAE.

References

Dec 1, 1979·Journal of the Neurological Sciences·H C RauchA Malley
Jul 1, 1973·Archives of Neurology·P O BehanJ B Lamarche
Jun 1, 1972·Canadian Journal of Biochemistry·M A BartonJ K Martin
Jun 1, 1970·Archives of Biochemistry and Biophysics·Y Oshiro, E H Eylar
May 1, 1980·Journal of the Neurological Sciences·E Frick, H Stickl
May 1, 1963·The Journal of Experimental Medicine·P Y PATERSON, S M HARWIN

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