PMID: 2487450Oct 1, 1989Paper

Experimental American trypanomiasis in rats: sympathetic denervation, parasitism and inflammatory process

Memórias do Instituto Oswaldo Cruz
C R Machado, A L Ribeiro

Abstract

Tissue parasitism, inflammatory process (histologic methods) and sympathetic denervation (glyoxylic acid-induced histofluorescence for demonstration of catecholamines) were studied in the heart (atrium and ventricle) and the submandibular gland of rats infected with the Y strain of Trypanosoma cruzi. In the heart paralleling intense parasitism and inflammatory process, the sympathetic denervation started at day-6 of infection and at the end of the acute phase (day 20) practically no varicose nerve terminals were found in both myocardium and vessels. In the submandibular gland, in spite of the rarity of amastigote pseudocysts and the scarcity of inflammatory foci, slight to moderate (days 13-15 of infection) or moderate to severe denervation (day 20) was found. At day 120 of infection both organs exhibited normal pattern of sympathetic innervation and only the heart showed some inflammatory foci and rare pseudocysts (ventricle). Our data suggest the involvement of circulating factors in the sympathetic denervation phenomena but indicate that local inflammatory process is, at least, an aggravating factor.

Citations

Aug 23, 2003·Experimental Parasitology·Deila J FrancoConceição R S Machado
Nov 15, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·L B GuerraC R Machado
Jul 28, 2001·Autonomic Neuroscience : Basic & Clinical·A L TeixeiraE R Camargos
May 17, 2011·Journal of Neuroparasitology·Marina V Chuenkova, Mercio Pereiraperrin
Dec 22, 2007·Digestive Diseases and Sciences·Leony Cristina CaetanoJosé Clóvis do Prado
Oct 31, 2009·International Journal of Cardiology·Antonio Luiz P RibeiroMaria Fernanda Lima-Costa
May 15, 2012·Experimental Physiology·Marcus Paulo Ribeiro Machado, Valdo Jose Dias da Silva
May 26, 2004·Microbes and Infection·Elizabeth R S CamargosConceição R S Machado
Jun 19, 2013·Journal of the American College of Cardiology·Maria Carmo Pereira NunesUNKNOWN Council on Chagas Disease of the Interamerican Society of Cardiology
Jul 31, 2014·Memórias do Instituto Oswaldo Cruz·Camila Megale de Almeida-LeiteRosa Maria Esteves Arantes

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