Aug 1, 1977

Experimental analysis of the complement-binding activity of gamma-globulin

Zhurnal mikrobiologii, epidemiologii, i immunobiologii
A P Ternovoĭ, E R Skrigan

Abstract

It was experimentally demonstrated that the anticomplimentary characteristics of gamma-globulin perparations was associated with disturbances of the colloid condition of the serum system and the absence of any stabilizing action of albumin and other serum proteins. It is also expressed as a result of a high complement-binding activity of protein aggregates. The anticomplementary characteristics of the nonaggregated part of protein in commercial preparations of gamma-globulin could be depressed by the addition of albumin or fresh serum; as to the anticomplementary characteristics of protein aggregates -- it remains unchanged. An intermolecular electrostatic interaction exists between albumin and gamma-globulin; it prevents sorption of the complement on Fc-fragment of IgG, whose destruction leads to the manifestation of the gamma-globulin complement-binding activity.

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Mentioned in this Paper

Depressed - Symptom
Complement Inactivator Proteins
ALB
Serum Proteins
Plasma Protein Binding Capacity
Hemolytic Complement
Gamma globulin
Plasma Albumin
ALB gene
Binding Activity [MoA]

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