PMID: 2098581Jan 1, 1990Paper

Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation

Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao
J Tao, K Y Feng

Abstract

In this study we observed the inhibitory effect of Chinese herbal medicine Ganoderma lucidum (GL) on platelet aggregation in 15 healthy volunteers and 33 patients with atherosclerotic diseases. The results showed that the first and the second phase of aggregation of platelets of the healthy volunteers were obviously inhibited (P less than 0.01) when watery soluble extract of GL of different concentrations was added to the platelets in vitro, i. e., the reaction speed of platelet aggregation was slowed down. The inhibitory effect was related to dosage. Platelet aggregation induced by ADP in final concentration of 2 mumol/L and 3 mumol/L was obviously inhibited, after the patients had taken GL 1 g 3 times a day for 2 weeks, the maximum platelet aggregation inhibition rates were then 31.49% (P less than 0.01) and 17.7% (P less than 0.01) respectively. Length and weights (wet and dry) of the extracorporeal thrombi were reduced from 30.05 +/- 4.38 mm, 103.9 +/- 9.33 mg and 44.89 +/- 4.79 mg to 20.4 +/- 2.33 mm (P less than 0.05), 85.27 +/- 8.77 mg (P less than 0.01) and 35.1 +/- 4.5 mg (P less than 0.01) respectively after oral administration of GL. The results of our experiments suggested that the Chinese herbal medicine GL may be ...Continue Reading

References

May 1, 1987·European Journal of Haematology·V M Steen, H Holmsen

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Citations

Jan 16, 2002·The American Journal of Chinese Medicine·Y H ShiehS C Li
Mar 3, 2005·Phytotherapy Research : PTR·Kar-Lok WongChi-Feng Liu
May 15, 2001·Phytotherapy Research : PTR·J M LeeY J Surh
Feb 17, 2015·The Cochrane Database of Systematic Reviews·Nerida L KluppAlan Bensoussan
Jun 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jian CuiQing-Wen Zhang
Aug 17, 2019·Current Vascular Pharmacology·Hoa Thi PhuGianfranco Pintus
Apr 23, 2020·Frontiers in Pharmacology·Abdullah ShaitoGianfranco Pintus
Sep 6, 2018·Applied Microbiology and Biotechnology·Kai-Di Hsu, Kuan-Chen Cheng
Dec 13, 2005·Molecular and Cellular Biochemistry·Connie W H WooKarmin O
May 7, 2005·Canadian Journal of Physiology and Pharmacology·Yaw L SiowKarmin O

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